Stine Knudsen Heier

• Juvodden, Hilde Therese; Alnæs, Dag; Agartz, Ingrid; Andreassen, Ole; Server, Andrés & Thorsby, Per Medbøe [Vis alle 8 forfattere av denne artikkelen] (2024). Cortical thickness and sub-cortical volumes in post-H1N1 narcolepsy type 1: A brain-wide MRI case-control study. Sleep Medicine. ISSN 1389-9457. 116, s. 81–89. doi: 10.1016/j.sleep.2024.02.031.
• Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole & Server, Andrés [Vis alle 9 forfattere av denne artikkelen] (2023). Larger hypothalamic volume in narcolepsy type 1. Sleep. ISSN 0161-8105. 46(11). doi: 10.1093/sleep/zsad173. Vis sammendrag

  Study Objectives: Narcolepsy type 1 (NT1) is a neurological sleep disorder. Postmortem studies have shown 75%–90% loss of the 50 000–70 000 hypocretin-producing neurons and 64%–94% increase in the 64 000–120 000 histaminergic neurons and conflicting indications of gliosis in the hypothalamus of NT1 patients. The aim of this study was to compare MRI-based volumes of the hypothalamus in patients with NT1 and controls in vivo. Methods: We used a segmentation tool based on deep learning included in Freesurfer and computed the volume of the whole hypothalamus, left/right part of the hypothalamus, and 10 hypothalamic subregions. We included 54 patients with post-H1N1 NT1 (39 females, mean age 21.8 ± 11.0 years) and 114 controls (77 females, mean age 23.2 ± 9.0 years). Group differences were tested with general linear models using permutation testing in Permutation Analysis of Linear Models and evaluated after 10 000 permutations, yielding two-tailed P-values. Furthermore, a stepwise Bonferroni correction was performed after dividing hypothalamus into smaller regions. Results: The analysis revealed larger volume for patients compared to controls for the whole hypothalamus (Cohen’s d = 0.71, p = 0.0028) and for the left (d = 0.70, p = 0.0037) and right part of the hypothalamus (d = 0.65, p = 0.0075) and left (d = 0.72, p = 0.0036) and right tubular-inferior (d = 0.71, p = 0.0037) hypothalamic subregions. Conclusions: In conclusion, patients with post-H1N1 NT1 showed significantly larger hypothalamic volume than controls, in particular in the tubular-inferior subregions which could reflect several processes as previous studies have indicated neuroinflammation, gliosis, and changes in the numbers of different cell types.

• Hansen, Berit M Hjelde; Andresen, Hilde Norsted; Gjesvik, Jonas; Thorsby, Per Medbøe; Nærland, Terje & Knudsen, Stine (2023). Associations between psychiatric comorbid disorders and executive dysfunctions in hypocretin-1 deficient pediatric narcolepsy type1. Sleep Medicine. ISSN 1389-9457. 109, s. 149–157. doi: 10.1016/j.sleep.2023.06.021. Fulltekst i vitenarkiv
• Viste, Rannveig; Follin, Louise Frøstrup; Kornum, Birgitte R.; Lie, Benedicte Alexandra; Viken, Marte Kathrine & Thorsby, Per Medbøe [Vis alle 9 forfattere av denne artikkelen] (2023). Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings. Sleep. ISSN 0161-8105. 46(3), s. 1–14. doi: 10.1093/sleep/zsac316. Fulltekst i vitenarkiv
• Cesari, Matteo; Heidbreder, Anna; St Louis, Erik K.; Sixel-Döring, Friederike; Bliwise, Donald L. & Baldelli, Luca [Vis alle 22 forfattere av denne artikkelen] (2022). Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group. Sleep. ISSN 0161-8105. 45(3). doi: 10.1093/sleep/zsab257.
• Viste, Rannveig; Viken, Marte Kathrine; Lie, Benedicte Alexandra; Juvodden, Hilde Therese; Nordstrand, Sebjørg E. H. & Thorsby, Per M. [Vis alle 9 forfattere av denne artikkelen] (2021). High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y<inf>11</inf>protein levels in narcolepsy type 1. Sleep. ISSN 0161-8105. 44(8), s. 1–12. doi: 10.1093/sleep/zsab062. Fulltekst i vitenarkiv
• Viste, Rannveig; Lie, Benedicte Alexandra; Viken, Marte Kathrine; Rootwelt, Terje; Knudsen-Heier, Stine & Kornum, Birgitte Rahbek (2021). Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status. Sleep Medicine. ISSN 1389-9457. 85, s. 271–279. doi: 10.1016/j.sleep.2021.07.024. Fulltekst i vitenarkiv
• Juvodden, Hilde Therese; Viken, Marte Kathrine; Nordstrand, Sebjørg Elizabeth Hesla; Viste, Rannveig; Westlye, Lars Tjelta & Thorsby, Per Medbøe [Vis alle 8 forfattere av denne artikkelen] (2020). HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives. Sleep. ISSN 0161-8105. 43(3), s. 1–11. doi: 10.1093/sleep/zsz239. Fulltekst i vitenarkiv
• Nordstrand, Sebjørg Elizabeth Hesla; Juvodden, Hilde Therese; Viste, Rannveig; Rootwelt-Revheim, Terje; Karlsen, Tor-Ivar & Thorsby, Per Medbøe [Vis alle 10 forfattere av denne artikkelen] (2020). Obesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign. Sleep. ISSN 0161-8105. 43(5). doi: 10.1093/sleep/zsz277.
• Hansen, Berit M Hjelde; Juvodden, Hilde Therese; Nordstrand, Sebjørg Elizabeth Hesla; Viste, Rannveig; Thorsby, Per Medbøe & Swanson, David [Vis alle 9 forfattere av denne artikkelen] (2020). High prevalence of ADHD symptoms in unmedicated youths with post-H1N1 narcolepsy type 1 . Sleep Medicine. ISSN 1389-9457. 75, s. 171–180. doi: 10.1016/j.sleep.2020.06.014. Fulltekst i vitenarkiv
• Pedersen, Natasja Wulff; Holm, Anja; Kristensen, Nikolaj Pagh; Bjerregaard, Anne-Mette; Bentzen, Amalie Kai & Marquard, Andrea Marion [Vis alle 13 forfattere av denne artikkelen] (2019). CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens. Nature Communications. ISSN 2041-1723. 10(837), s. 1–12. doi: 10.1038/s41467-019-08774-1.
• Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Dietrichs, Espen; Thorsby, Per Medbøe & Westlye, Lars Tjelta [Vis alle 7 forfattere av denne artikkelen] (2019). Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing. Sleep. ISSN 0161-8105. 42:zsz082(7), s. 1–12. doi: 10.1093/sleep/zsz082. Fulltekst i vitenarkiv
• Nordstrand, Sebjørg Elizabeth Hesla; Hansen, Berit M Hjelde; Rootwelt-Revheim, Terje; Karlsen, Tor-Ivar; Swanson, David & Nilsen, Kristian Bernhard [Vis alle 7 forfattere av denne artikkelen] (2019). Psychiatric symptoms in patients with post-H1N1 narcolepsy type 1 in Norway. Sleep. ISSN 0161-8105. 42(4), s. 1–9. doi: 10.1093/sleep/zsz008. Vis sammendrag

  Study Objectives Several studies have reported psychiatric comorbidity in patients with narcolepsy type 1 (NC1). The primary aim of this study was to explore the extent of psychiatric symptoms in a cohort of Norwegian NC1 patients, most of whom were H1N1-vaccinated. We also wanted to explore possible causes of the psychiatric symptoms seen in NC1. Methods Cross-sectional study. Psychiatric symptoms were assessed by the Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Check List (CBCL) in children and by Adult Self Report (ASR) in adults. Results The mean (SD) total T-scores were 58.6 (9.2) for children and 57.0 (9.8) for adults, these being mainly driven by internalizing problems. Internalizing symptom T-scores showed that 37.5% of the children and 33.3% of the adults were in the clinical range of concern. T-scores were lower when the questionnaire’s sleep-related items were excluded. However, 27.5% of children and 22.2% of adults still remained within the total psychiatric symptoms clinical range. Psychiatric symptoms and excessive daytime sleepiness were not associated. However, in children fragmented sleep, measured by sleep-stage shift index was significantly negatively associated with all the psychiatric summary scores (all p ≤ 0.020), and awakening index was negatively associated with externalizing (p = 0.042) and total summary scores (p = 0.042). In adults, awakening index, but not sleep-stage shift index, was positively associated with internalizing score (p = 0.015). Hypocretin-1 levels showed no association with psychiatric symptoms. Conclusions We found a high prevalence of psychiatric symptoms in NC1 patients. Fragmented sleep was significantly associated with psychiatric symptoms. Keywords: narcolepsy type 1, narcolepsy with cataplexy, psychiatric symptoms, Pandemrix, H1N1

• Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas & Dietrichs, Espen [Vis alle 9 forfattere av denne artikkelen] (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep. ISSN 0161-8105. 41(10). doi: 10.1093/sleep/zsy145. Fulltekst i vitenarkiv
• Nordstrand, Sebjørg Elizabeth Hesla; Hansen, Berit M Hjelde; Kamaleri, Yusman; Nilsen, Kristian Bernhard; Rootwelt-Revheim, Terje & Karlsen, Tor-Ivar [Vis alle 7 forfattere av denne artikkelen] (2018). Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study. Sleep Medicine. ISSN 1389-9457. 50, s. 175–180. doi: 10.1016/j.sleep.2018.05.037. Fulltekst i vitenarkiv Vis sammendrag

  Objective Cross-sectional studies show a lower health-related quality of life (HRQoL) in individuals with narcolepsy. We aimed to describe changes in HRQoL after two years of multidisciplinary follow-up in a cohort of mainly post-H1N1 vaccination narcolepsy type-1 (NT1) patients in Norway. Methods Prospective-cohort study. Narcolepsy diagnosis was based on the International Classification of Sleep Disorders (third edition). Psychiatric comorbidity was assessed using the Achenbach System of Empirically Based Assessment (ASEBA). HRQoL was evaluated with the Pediatric Quality of Life Inventory (PedsQL™ Generic Core Scales 4.0) at baseline and follow-up. Mean follow-up time was 20.7 (2.7) months. Results Thirty one patients (18 females) with NT1, mean age 14.6 (SD = 4.8) years answered questionnaires at baseline and follow-up. On a group level, the PedsQL Total Health Summary score significantly improved by a mean of 5.9 (95%CI = 0.4, 11.9), p = 0.038; this was mainly driven by improvements in the Physical Health Summary score by 9.8 (3.0, 16.5) points, p = 0.006 and the School Functioning Scale score by 7.5 (1.0, 13.9) points p = 0.025. The Total ASEBA score was correlated with PedsQL Total Health Summary score at baseline, but not with changes in HRQoL. Sodium oxybate (Xyrem®) treatment at follow up was positively associated with changes in PedsQL Total Health Summary score, after adjusting for age and gender, p = 0.027. Conclusion HRQoL in NT1 patients improved after two years of follow-up. The use of sodium oxybate (Xyrem®) at follow-up was associated with increases in HRQoL. Psychiatric comorbidity was correlated with HRQoL at baseline but did not predict changes in HRQoL at follow-up.

• Kornum, Birgitte Rahbek; Burgdorf, Kristoffer Sølvsten; Holm, Anja; Ullum, Henrik; Jennum, Poul & Knudsen, Stine (2017). Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot. Journal of Neuroimmunology. ISSN 0165-5728. 309, s. 7–11. doi: 10.1016/j.jneuroim.2017.05.001.
• Schrolkamp, Maren; Jennum, Poul J.; Gammeltoft, Steen; Holm, Anja; Kornum, Birgitte Rahbek & Knudsen, Stine (2017). Normal morning melanin-concentrating hormone levels and no association with rapid eye movement or non-rapid eye movement sleep parameters in narcolepsy type 1 and type 2. Journal of Clinical Sleep Medicine (JCSM). ISSN 1550-9389. 13(2), s. 235–243. doi: 10.5664/jcsm.6454.
• Viste, Rannveig; Soosai, Joseph; Vikin, Truls; Thorsby, Per Medbøe; Nilsen, Kristian Bernhard & Knudsen, Stine (2017). Long-Term improvement after combined immunomodulation in early post-H1N1 vaccination narcolepsy. Neurology: Neuroimmunology and neuroinflammation. ISSN 2332-7812. 4(5). doi: 10.1212/NXI.0000000000000389. Fulltekst i vitenarkiv
• Kornum, Birgitte Rahbek; Knudsen, Stine; Ollila, Hanna Maria; Pizza, Fabio; Jennum, Poul Jørgen & Dauvilliers, Yves [Vis alle 7 forfattere av denne artikkelen] (2017). Narcolepsy. Nature Reviews Disease Primers. ISSN 2056-676X. 3, s. 1–19. doi: 10.1038/nrdp.2016.100.
• Jennum, Poul J.; Kornum, Birgitte Rahbek; Issa, Nadia M.; Gammeltoft, Steen; Tommerup, Niels & Morling, Niels [Vis alle 8 forfattere av denne artikkelen] (2016). Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis. Neurology: Neuroimmunology and neuroinflammation. ISSN 2332-7812. 3. doi: 10.1212/NXI.0000000000000249.
• Kornum, Birgitte Rahbek; Pizza, Fabio; Knudsen, Stine; Plazzi, Giuseppe; Jennum, Poul & Mignot, Emmanuel (2015). Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset. Brain, Behavior, and Immunity. ISSN 0889-1591. 49, s. 54–58. doi: 10.1016/j.bbi.2015.03.004.
• Barloese, Mads; Jennum, Poul; Lund, Nunu; Knudsen, Stine; Gammeltoft, Steen & Jensen, Rigmor (2015). Reduced CSF hypocretin-1 levels are associated with cluster headache. Cephalalgia. ISSN 0333-1024. 35(10), s. 869–876. doi: 10.1177/0333102414562971.
• Ollila, Hanna M.; Ravel, Jean-Marie; Han, Fang; Faraco, Juliette; Lin, Ling & Zheng, Xiuwen [Vis alle 34 forfattere av denne artikkelen] (2015). HLA-DPB1 and HLA class i confer risk of and protection from narcolepsy. American Journal of Human Genetics. ISSN 0002-9297. 96(1), s. 136–146. doi: 10.1016/j.ajhg.2014.12.010.
• Holm, Anja; Bang-Berthelsen, Claus Heiner; Knudsen, Stine; Modvig, Signe; Kornum, Birgitte Rahbek & Gammeltoft, Steen [Vis alle 7 forfattere av denne artikkelen] (2014). MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias. Journal of the Neurological Sciences. ISSN 0022-510X. 347(1-2), s. 199–204. doi: 10.1016/j.jns.2014.09.047.
• Han, Fang; Lin, Ling; Schormair, Barbara; Pizza, Fabio; Plazzi, Giuseppe & Ollila, Hanna M. [Vis alle 17 forfattere av denne artikkelen] (2014). HLA DQB1∗06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep. ISSN 0161-8105. 37(10), s. 1601–1608. doi: 10.5665/sleep.4066.
• Heier, Mona Frederikke Jayne Skard; Gjerstad, Michaela-Alexandra Dreetz & Knudsen, Stine (2013). Ny kunnskap om narkolepsi hos barn. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133(12-13), s. 1326–1328. doi: 10.4045/tidsskr.13.0414.

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• Plazzi, Giuseppe; Pizza, Fabio; Lecendreux, Michel; Gringras, Paul; Barateau, Lucie & Bruni, Oliviero [Vis alle 22 forfattere av denne artikkelen] (2023). Letter to editor. Journal of Sleep Research. ISSN 0962-1105. doi: 10.1111/jsr.14055.
• Cesari, Matteo; Heidbreder, Anna; St Louis, Erik K.; Sixel-Döring, Friederike; Bliwise, Donald L. & Baldelli, Luca [Vis alle 22 forfattere av denne artikkelen] (2023). Polysomnographic diagnosis of REM sleep behavior disorder: a change is needed. Sleep. ISSN 0161-8105. 46(1). doi: 10.1093/sleep/zsac276.
• Hansen, Berit M Hjelde & Knudsen, Stine (2018). ADHD symptoms in H1N1-vaccinated youths with narcolepsy type 1.
• Engstrøm, Morten; Aarrestad, Sigurd; Eldøen, Guttorm; Alme, Anders; Bjørge, Trond & Miljeteig, Harald [Vis alle 10 forfattere av denne artikkelen] (2018). Nye anbefalinger for objektiv undersøkelse av søvn og søvnforstyrrelser. . Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(19), s. 1805–1806. doi: 10.4045/tidsskr.18.0741.
• Andresen, Hilde; Hansen, Berit M Hjelde; Bronder, Knut Halvard; Juvodden, Hilde Therese & Knudsen, Stine (2017). Psychiatric Comorbidity and Executive Function after onset of narcolepsy.
• Hansen, Berit M Hjelde & Knudsen, Stine (2017). ADHD SYMPTOMS IN UNMEDICATED YOUTHS WITH NARCOLEPSY TYPE 1.Poster ESCAP Geneve 2017. Hansen BH, Knudsen S.
• Nordstrand, Sebjørg Elizabeth Hesla; Hansen, Berit M Hjelde; Kamaleri, Yusman; Nilsen, Kristian Bernhard; Karlsen, Tor-Ivar & Knudsen, Stine (2017). Changes in Quality of Life in individuals with narcolepsy in Norway after H1N1-influensa epidemic in 2009- a 2-year prospective cohort study.
• Hansen, Berit Marina Hjelde & Knudsen, Stine (2017). ADHD symptoms in unmedicated youths with Narcolepsy type 1.
• Andresen, Hilde K; Hansen, Berit Marina Hjelde; Bronder, Knut Halvard; Juvodden, Hilde Therese & Knudsen, Stine (2016). Narcolepsy type 1 is associated with executive dysfunction.

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