Faglige interesser
- urologi
- kreft i nyre, blære og prostata
- urogenitale infeksjoner
Bakgrunn
- Cand. med. 1976, Universitetet i Oslo
- Spesialist i generell kirurgi 1984, urologi 1986
- Dr. med. 1988, Universitetet i Oslo
- Professor i urologi og instituttsjef i Norsk Institutt for Urologi, Universitetet i Tromsø,1993-2001
- Norsk prostatakreftregister, 2001-2002
- Professor i medisinske fag, Høgskolen i Telemark, 2002-2005
- Professor II i urologi, Århus Universitetet, 2007-2012
- Klinisk erfaring som seksjonsleder sykehuset i Telemark 1988 - 2007, og ledende overlege ved Århus Universitetssykehus 2007-2012
- Overlege i urologi, Oslo Universitetssykehus siden 2013
Verv
- Board member, EAU Research Foundation (EAURF)
- Faculty member, European School of Urology
- Co-chairman, Global Prevalence-Study on Infections in Urology (GPIU)
- Co-chairman EAURF/ - GPIU-Serpens study on urosepsis
- Past chair European Section for Infections in Urology (ESIU), a full section of the European Association of Urology (EAU) (Chair/co-chair 2000-2016)
- Past co-chair of EAU guidelines panel on Urogenital Infections (Co-chair 2000-2016)
- Board member and Commissioner for Europe, Commission for UTI, International Society for Chemotherapy of Infection and Cancer
- Secretary for EU CAP (EUropean registry for Cryosurgical Ablation of Prostate cancer)
- Ass editor Technologies in Cancer Research and Treatment, US
- Section editor, European Urology To-day
- Referee/ consulting editor for numerous medical journals
- Member of EU (ECDC) advisory board on antibiotic resistance
- Leder av Blærekreftforeningens nasjonale, medisinske fagråd
Publikasjoner
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Tandogdu, Zafer; Koves, Bela; Ristovski, Slobodan; Balci, Mustafa Bahadir Can; Rennesund, Kristin & Gravas, Stavros
[Vis alle 18 forfattere av denne artikkelen]
(2024).
Urosepsis 30-day mortality, morbidity, and their risk factors: SERPENS study, a prospective, observational multi-center study.
World Journal of Urology.
ISSN 0724-4983.
42(1).
doi:
10.1007/s00345-024-04979-2.
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Tommaso, Cai; Tamanini, Irene; Odorizzi, Katia; Gallelli, Luca; Lanzafame, Massimiliano & Mazzoli, Sandra
[Vis alle 12 forfattere av denne artikkelen]
(2024).
The diagnostic yield of the Meares & Stamey test can be significantly improved by symptom-based patient selection and the experience of the test performer.
Prostate Cancer and Prostatic Diseases.
ISSN 1365-7852.
doi:
10.1038/s41391-024-00824-0.
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Bellankimath, Anurag Basavaraj; Chapagain, Crystal; Branders, Sverre; Ali, Jawad; Wilson, Robert Charles & Johansen, Truls E. Bjerklund
[Vis alle 7 forfattere av denne artikkelen]
(2024).
Detection of pathogens and antimicrobial resistant genes from urine within 5 hours using Nanopore sequencing.
bioRxiv.
ISSN 2692-8205.
doi:
10.1101/2024.03.04.582689.
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Cai, Tommaso; Verze, Paolo; Arcaniolo, Davide; Pandolfo, Savio Domenico; Smarrazzo, Francesco & Manfredi, Celeste
[Vis alle 13 forfattere av denne artikkelen]
(2023).
Antibiotic Resistance Patterns Among Uropathogens in Female Outpatients Affected by Uncomplicated Cystitis: Focus on Fosfomycin Trometamol.
International Journal of Antimicrobial Agents.
ISSN 0924-8579.
62(5).
doi:
10.1016/j.ijantimicag.2023.106974.
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Tommaso, Cai; Gallelli, Luca; Cione, Erika; Verze, Paolo; Palmieri, Alessandro & Mirone, Vincenzo
[Vis alle 9 forfattere av denne artikkelen]
(2022).
The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study.
Minerva Urology and Nephrology.
ISSN 2724-6051.
74(6),
s. 780–788.
doi:
10.23736/S2724-6051.21.04141-2.
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Tutone, Michaela; Johansen, Truls Erik Bjerklund; Cai, Tommaso; Mushtaq, Shazad & Livermore, David M.
(2022).
SUsceptibility and Resistance to Fosfomycin and other antimicrobial agents among pathogens causing lower urinary tract infections: findings of the SURF study.
International Journal of Antimicrobial Agents.
ISSN 0924-8579.
s. 1–7.
doi:
10.1016/j.ijantimicag.2022.106574.
Fulltekst i vitenarkiv
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Tandogdu, Zafer; Collins, Justin W.; Shaw, Greg; Rohn, Jennifer; Köves, Béla & Sachdeva, Ashwin
[Vis alle 42 forfattere av denne artikkelen]
(2021).
Management of patients who opt for radical prostatectomy during the coronavirus disease 2019 (COVID-19) pandemic: an international accelerated consensus statement.
BJU International.
ISSN 1464-4096.
127(6),
s. 729–741.
doi:
10.1111/bju.15299.
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Cai, Tommaso; Cocci, Andrea; Maida, Fabrizio Di; Chiodini, Stefano; Ciarleglio, Francesco & Luciani, Lorenzo Giuseppe
[Vis alle 12 forfattere av denne artikkelen]
(2021).
Visceral adiposity is associated with worse urinary and sexual function recovery after radical prostatectomy: Results from a longitudinal cohort study.
Archivio Italiano di Urologia e Andrologia.
ISSN 1124-3562.
93(3),
s. 285–290.
doi:
10.4081/aiua.2021.3.285.
Fulltekst i vitenarkiv
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Cai, Tommaso; Tiscione, Daniele; Favilla, Vincenzo; Puglisi, Marco; Palumbo, Fabrizio & Zucchi, Alessandro
[Vis alle 9 forfattere av denne artikkelen]
(2020).
Oral administration and intralesional injection of hyaluronic acid Versus intralesional injection alone in peyronie's disease: Results from a phase III study.
The World Journal of Men's Health (WJMH).
ISSN 2287-4208.
38.
doi:
10.5534/WJMH.200048.
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Cai, Tommaso; Tamanini, Irene; Mattevi, Daniele; Verze, Paolo; Palmieri, Alessandro & Malossini, Gianni
[Vis alle 10 forfattere av denne artikkelen]
(2020).
Fosfomycin trometamol and N-acetyl-L-cysteine as combined oral therapy of difficult-to-treat chronic bacterial prostatitis: Results of a pilot study.
International Journal of Antimicrobial Agents.
ISSN 0924-8579.
doi:
10.1016/j.ijantimicag.2020.105935.
Vis sammendrag
This paper presents the results of a pilot study of difficult-to-treat patients (exhibiting several previous treatment failures or detection of extended-spectrum beta-lactamase [ESBL] strains) with chronic bacterial prostatitis (CBP) who underwent treatment with fosfomycin trometamol (FT) and N-acetyl-L-cysteine (NAC). Twenty-eight patients with clinically- and microbiologically-confirmed CBP who attended a single urological institution between January 2018 and March 2019 were treated with oral administration of 3 g FT once a day for 2 days, followed by a dose of 3 g every 48 h for 2 weeks, in combination with oral administration of NAC 600 mg once a day for 2 weeks. Clinical and microbiological analyses were carried out at the time of admission (T0) and during follow-up at 1 month (T1) and 6 months (T2) after the end of treatment. Symptoms were assessed by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and International Prostatic Symptom Score (IPSS), and quality of life was assessed by Quality of Well-Being (QoL) questionnaires. Isolated strains were Escherichia coli (23 patients), Enterococcus spp. (3 patients), and Klebsiella oxytoca (2 patients). ESBL strain was found in 19 (67.8%) patients. Microbiological eradication was documented in 21 (75%) patients at the second follow-up visit and clinical cure was achieved in 20 (71.4%) patients. Significant changes on questionnaires were recorded between baseline and follow-up visits. Fifteen of 19 patients (78.9%) with ESBL strains were cured. No significant side effects were reported. FT in combination with NAC is a promising alternative therapy in difficult-to-treat CBP patients.
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Wagenlehner, Florian M.; Johansen, Truls Erik Bjerklund; Cai, Tommaso; Köves, Béla; Kranz, Jennifer & Pilatz, Adrian
[Vis alle 7 forfattere av denne artikkelen]
(2020).
Epidemiology, definition and treatment of complicated urinary tract infections.
Nature reviews. Urology.
ISSN 1759-4812.
17(10),
s. 586–600.
doi:
10.1038/s41585-020-0362-4.
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Matthew, Dixon; Stefil, Maria; McDonald, Michael; Johansen, Truls Erik Bjerklund; Naber, Kurt & Wagenlehner, Florian M.
[Vis alle 7 forfattere av denne artikkelen]
(2019).
Metagenomics in diagnosis and improved targeted treatment of UTI.
World Journal of Urology.
ISSN 0724-4983.
38,
s. 35–43.
doi:
10.1007/s00345-019-02731-9.
Vis sammendrag
Introduction The genomic revolution has transformed our understanding of urinary tract infection. There has been a paradigm
shift from the dogmatic statement that urine is sterile in healthy people, as we are becoming forever more familiar with the
knowledge that bacterial communities exist within the urinary tracts of healthy people. Metagenomics can investigate the
broad populations of microbial communities, analysing all the DNA present within a sample, providing comprehensive data
regarding the state of the microenvironment of a patient’s urinary tract. This permits medical practitioners to more accurately
target organisms that may be responsible for disease—a form of ‘precision medicine’.
Methods and Results This paper is derived from an extensive review and analysis of the available literature on the topic of
metagenomic sequencing in urological science, using the PubMed search engine. The search yielded a total of 406 results,
and manual selection of appropriate papers was subsequently performed. Only one randomised clinical trial comparing
metagenomic sequencing to standard culture and sensitivity in the arena of urinary tract infection was found.
Conclusion Out of this process, this paper explores the limitations of traditional methods of culture and sensitivity and
delves into the recent studies involving new high-throughput genomic technologies in urological basic and clinical research,
demonstrating the advances made in the urinary microbiome in its entire spectrum of pathogens and the first attempts of
clinical implementation in several areas of urology. Finally, this paper discusses the challenges that must be overcome for
such technology to become widely used in clinical practice.
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Cai, Tommaso; Tamanini, Irene; Tascini, Carlo; Köves, Bela; Bonkat, Gernot & Gacci, Mauro
[Vis alle 10 forfattere av denne artikkelen]
(2019).
Fosfomycin Trometamol versus Comparator Antibiotics for the Treatment of Acute Uncomplicated Urinary Tract Infections in Women: A Systematic Review and Meta-Analysis.
Journal of Urology.
ISSN 0022-5347.
203(3),
s. 570–578.
doi:
10.1097/JU.0000000000000620.
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Tandogdu, Zafer; Kakariadis, Evgenios TA; Naber, Kurt; Wagenlehner, Florian & Johansen, Truls Erik Bjerklund
(2019).
Appropriate empiric antibiotic choices in health care associated urinary tract infections in urology departments in Europe from 2006 to 2015: A Bayesian analytical approach applied in a surveillance study.
PLOS ONE.
ISSN 1932-6203.
14(4),
s. 1–18.
doi:
10.1371/journal.pone.0214710.
Fulltekst i vitenarkiv
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Köves, Béla; Tenke, Peter; Tandogdu, Zafer; Cai, Tommaso; Bogenhard, Florian & Wullt, Björn
[Vis alle 15 forfattere av denne artikkelen]
(2018).
Transurethral resection of the prostate: Are we following the guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) study.
Journal of chemotherapy.
ISSN 1120-009X.
31(1),
s. 15–22.
doi:
10.1080/1120009X.2018.1542552.
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Cai, Tommaso; Cocci, Andrea; Verze, Paolo; Rizzo, Michele; Palmieri, Alessandro & Liguori, Giovanni
[Vis alle 15 forfattere av denne artikkelen]
(2018).
The use of oral fosfomycin-trometamol in patients with catheter-associated urinary tract infections (CAUTI): new indications for an old antibiotic?
Journal of chemotherapy.
ISSN 1120-009X.
30(5),
s. 290–295.
doi:
10.1080/1120009X.2018.1500110.
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Choe, Hyun-Sop; Lee, Seung-Ju; Cho, Yong-Hyun; Cek, Mete; Tandogdu, Zafer & Wagenlehner, Florian
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Aspects of urinary tract infections and antimicrobial resistance in hospitalized urology patients in Asia: 10-Year results of the Global Prevalence Study of Infections in Urology (GPIU).
Journal of Infection and Chemotherapy.
ISSN 1341-321X.
24(4),
s. 278–283.
doi:
10.1016/j.jiac.2017.11.013.
Fulltekst i vitenarkiv
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Cai, Tommaso; Tessarolo, Francesco; Caola, Iole; Piccoli, Federico; Nollo, Giandomenico & Caciagli, Patrizio
[Vis alle 12 forfattere av denne artikkelen]
(2018).
Prostate calcifications: A case series supporting the microbial biofilm theory.
Investigative and Clinical Urology (Investig. clin. urol.).
ISSN 2466-0493.
59(3),
s. 187–193.
doi:
10.4111/icu.2018.59.3.187.
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Cai, Tommaso; Lanzafame, Paolo; Caciagli, Patrizio; Migno, Serena; Mereu, Liliana & Mattevi, Daniele
[Vis alle 10 forfattere av denne artikkelen]
(2018).
Role of increasing leukocyturia for detecting the transition from asymptomatic bacteriuria to symptomatic infection in women with recurrent urinary tract infections: A new tool for improving antibiotic stewardship.
International journal of urology.
ISSN 0919-8172.
25(9),
s. 800–806.
doi:
10.1111/iju.13723.
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Cai, Tommaso; Cocci, Andrea; Tiscione, Daniele; Puglisi, Marco; Di Maida, Fabrizio & Malossini, Gianni
[Vis alle 10 forfattere av denne artikkelen]
(2018).
L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts are not inferior to antibiotic treatment for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections: Focus on antibiotic-sparing approach.
Archivio Italiano di Urologia e Andrologia.
ISSN 1124-3562.
9(2),
s. 97–100.
doi:
10.4081/aiua.2018.2.97.
Fulltekst i vitenarkiv
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Cai, Tommaso; Verze, Paolo; Palmieri, Alessandro; Gacci, Mauro; Lanzafame, Paolo & Malossini, Gianni
[Vis alle 12 forfattere av denne artikkelen]
(2017).
Is preoperative assessment and treatment of asymptomatic bacteriuria necessary for reducing the risk of postoperative symptomatic urinary tract infections after urologic surgical procedures?
Urology.
ISSN 0090-4295.
99,
s. 100–105.
doi:
10.1016/j.urology.2016.10.016.
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Cai, Tommaso; Tamanini, Irene; Kulchavenya, Ekaterina; Perepanova, Tamara; Köves, Béla & Wagenlehner, Florian M.E.
[Vis alle 10 forfattere av denne artikkelen]
(2017).
The role of nutraceuticals and phytotherapy in the management of urinary tract infections: What we need to know?
Archivio Italiano di Urologia e Andrologia.
ISSN 1124-3562.
89(1),
s. 1–6.
doi:
10.4081/aiua.2017.1.1.
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Drejer, Ditte; Beji, Sami; Øzeke, Recep; Nielsen, Anna Munk; Høyer, Søren & Johansen, Truls Erik Bjerklund
[Vis alle 8 forfattere av denne artikkelen]
(2017).
Comparison of White Light, Photodynamic Diagnosis, and Narrow-band Imaging in Detection of Carcinoma In Situ or Flat Dysplasia at Transurethral Resection of the Bladder: the DaBlaCa-8 Study.
Urology.
ISSN 0090-4295.
102,
s. 138–142.
doi:
10.1016/j.urology.2016.11.032.
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Cai, Tommaso; Köves, Béla & Johansen, Truls Erik Bjerklund
(2017).
Asymptomatic bacteriuria, to screen or not to screen - And when to treat?
Current Opinion in Urology.
ISSN 0963-0643.
27(2),
s. 107–111.
doi:
10.1097/MOU.0000000000000368.
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Wagenlehner, Florian M.E.; Tandogdu, Zafer & Johansen, Truls Erik Bjerklund
(2017).
An update on classification and management of urosepsis.
Current Opinion in Urology.
ISSN 0963-0643.
27(2),
s. 133–137.
doi:
10.1097/MOU.0000000000000364.
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Tandogdu, Zafer; Cai, Tommaso; Köves, Béla; Wagenlehner, Florian & Johansen, Truls Erik Bjerklund
(2016).
Urinary tract infections in immunocompromised patients with diabetes, chronic kidney disease, and kidney transplant.
European Urology Focus.
ISSN 2405-4569.
2(4),
s. 394–399.
doi:
10.1016/j.euf.2016.08.006.
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Cai, Tommaso; Verze, Paolo; Brugnolli, Anna; Tiscione, Daniele; Luciani, Lorenzo Giuseppe & Eccher, Cristina
[Vis alle 13 forfattere av denne artikkelen]
(2016).
Adherence to European Association of Urology Guidelines on Prophylactic Antibiotics: An Important Step in Antimicrobial Stewardship.
European Urology.
ISSN 0302-2838.
69(2),
s. 276–283.
doi:
10.1016/j.eururo.2015.05.010.
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Vahlensieck, Winfried; Perepanova, Tamara; Johansen, Truls Erik Bjerklund; Tenke, Peter; Naber, Kurt G. & Wagenlehner, Florian M.E.
(2016).
Management of uncomplicated recurrent urinary tract infections.
European Urology. Supplement.
ISSN 1569-9056.
15(4),
s. 95–101.
doi:
10.1016/j.eursup.2016.04.007.
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Mouraviev, V; Lee, B; Patel, V; Albala, D; Johansen, Truls Erik Bjerklund & Partin, A.
[Vis alle 8 forfattere av denne artikkelen]
(2016).
Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer.
Prostate Cancer and Prostatic Diseases.
ISSN 1365-7852.
19(1),
s. 14–20.
doi:
10.1038/pcan.2015.48.
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Bartoletti, Riccardo; Cai, Tommaso; Perletti, Giampaolo; Wagenlehner, Florian M.E. & Johansen, Truls E. Bjerklund
(2015).
Finafloxacin for the treatment of urinary tract infections.
Expert Opinion on Investigational Drugs.
ISSN 1354-3784.
24(7),
s. 957–963.
doi:
10.1517/13543784.2015.1052401.
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Johansen, Truls Erik B; Nilsson, Rasmus; Tandogdu, Zafer & Wagenlehner, Florian
(2014).
Clinical presentation, risk factors and use of antibiotics in urinary tract infections.
Surgery (United Kingdom).
ISSN 0263-9319.
32(6),
s. 297–303.
doi:
10.1016/j.mpsur.2014.04.002.
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Baust, John G.; Gage, Andrew A.; Johansen, Truls Erik B & Baust, John M.
(2014).
Mechanisms of cryoablation: Clinical consequences on malignant tumors.
Cryobiology.
ISSN 0011-2240.
68(1),
s. 1–11.
doi:
10.1016/j.cryobiol.2013.11.001.
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Nilsson, Rasmus; Omland, Harald; Dahl, Alv A & Johansen, Truls Erik B
(2014).
Early outcome of orchiopexy and analysis of predictive factors: A retrospective study from 2001 to 2010 in a Norwegian regional hospital.
Scandinavian Journal of Urology.
ISSN 2168-1805.
48(5),
s. 474–481.
doi:
10.3109/21681805.2014.905631.
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Tenke, Peter; Köves, Béla & Johansen, Truls Erik B
(2014).
An update on prevention and treatment of catheter-associated urinary tract infections.
Current Opinion in Infectious Diseases.
ISSN 0951-7375.
27(1),
s. 102–107.
doi:
10.1097/QCO.0000000000000031.
Se alle arbeider i Cristin
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Johansen, Truls Erik Bjerklund & Zahl, Per Henrik
(2023).
T.E.B. Johansen og P.H. Zahl svarer.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
143(12).
doi:
10.4045/tidsskr.23.0529.
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Johansen, Truls Erik Bjerklund & Zahl, Per Henrik
(2023).
Er det bedre å ikke utføre PSA-test?
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
143(8),
s. 671–671.
doi:
10.4045/tidsskr.23.0248.
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Johansen, Truls Erik Bjerklund & Cai, Tommaso
(2022).
Facing urosepsis- the most deadly of all urological diseases: Editorial comment to ‘Community-onset urosepsis; incidence and risk factors for 30-day mortality- a retrospective cohort study’, by Holmbom M. et al.
Scandinavian Journal of Urology.
ISSN 2168-1805.
56(5),
s. 421–422.
doi:
10.1080/21681805.2022.2137230.
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Cai, Tommaso; Caffo, Orazio; Malossini, Gianni & Johansen, Truls Erik Bjerklund
(2021).
Delaying Cancer Cases in Urology during COVID-19: Review of the Literature. Letter.J Urol 2020; 204: 926.
Journal of Urology.
ISSN 0022-5347.
205(5),
s. 1534–1535.
doi:
10.1097/JU.0000000000001643.
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Gjersvik, Petter; Heikkilä, Reino & Johansen, Truls Erik Bjerklund
(2021).
Redningsbehandling ved kreft.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
141(5),
s. 1–3.
doi:
10.4045/tidsskr.21.0084.
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Cai, Tommaso; Tandogdu, Zafer; Wagenlehner, Florian M E & Johansen, Truls Erik Bjerklund
(2020).
Re: COVID-19 Coagulopathy: Considerations for UrologistsJ. S. Jue and M. Alameddine J Urol 2020; 204: Epub ahead of print. doi: 10.1097/JU.0000000000001144.
Journal of Urology.
ISSN 0022-5347.
204(4),
s. 848–849.
doi:
10.1097/JU.0000000000001228.
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Cai, Tommaso; Verze, Paolo; Luciani, Lorenzo; Malossini, Gianni; Johansen, Truls Erik Bjerklund & Benetollo, Pier P.
[Vis alle 7 forfattere av denne artikkelen]
(2020).
What do Patients Say about Telephone-based Urological Consultations at the Time of the COVID-19 Pandemic?
Minerva Urologica e Nefrologica.
ISSN 0393-2249.
72(4),
s. 515–516.
doi:
10.23736/S0393-2249.20.03940-5.
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Johansen, Truls Erik Bjerklund & Cai, Tommaso
(2018).
Re: Determinants of variable resource use for multidisciplinary team meetings in cancer care.
European Urology.
ISSN 0302-2838.
s. 1–1.
doi:
10.1016/j.eururo.2018.10.037.
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Smelov, Vitaly; Naber, Kurt & Johansen, Truls Erik Bjerklund
(2016).
Letter to the editor: Diagnostic criteria in urological diseases do not always match with findings by extended culture techniques and metagenomic sequencing of 16S rDNA.
Open Microbiology Journal.
ISSN 1874-2858.
10,
s. 23–26.
doi:
10.2174/1874285801610010023.
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Johansen, Truls Erik Bjerklund
(2015).
Re: Ulike retningslinjer for behandling av prostatakreft.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
135(17),
s. 1535–1536.
doi:
10.4045/tidsskr.15.0928.
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Johansen, Truls Erik Bjerklund
(2015).
Re: Den vanskelige prostatakreften.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
135(17).
doi:
10.4045/tidsskr.15.0915.
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Johansen, Truls Erik Bjerklund
(2015).
Ulike retningslinjer for behandling av prostatakreft :.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
135(10),
s. 924–925.
doi:
10.4045/tidsskr.15.0317.
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Johansen, Truls E. Bjerklund
(2015).
Den vanskelige prostatakreften.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
135(6).
doi:
10.4045/tidsskr.15.0057.
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Publisert
27. sep. 2013 15:28
- Sist endret
11. sep. 2020 07:45