Vidar Søyseth

• Hardang, Ingrid Marie; Søyseth, Vidar; Kononova, Natalia; Hagve, Tor Arne & Einvik, Gunnar (2024). COPD: Iron Deficiency and Clinical Characteristics in Patients With and Without Chronic Respiratory Failure. Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation. 11(3), s. 261–269. doi: 10.15326/jcopdf.2023.0477.
• Ruud, Espen Asak; Heck, Sigurd; Stavem, Knut; Søyseth, Vidar; Geitung, Jonn Terje & Ashraf, Haseem (2022). Low diffusion capacity of the lung predicts pneumothorax and chest drainage after CT-guided lung biopsy. BMC Research Notes. ISSN 1756-0500. 15(1). doi: 10.1186/s13104-022-06234-6. Fulltekst i vitenarkiv
• Kononova, Natalia; Einvik, Gunnar; Holmedahl, Nils Henrik; Hagve, Tor-Arne; Omland, Torbjørn & Søyseth, Vidar (2022). It is unlikely that oxygen supplementation in COPD patients with chronic respiratory failure reduce cardiac troponin level. BMC Pulmonary Medicine. ISSN 1471-2466. 22, s. 1–8. doi: 10.1186/s12890-022-02169-7. Fulltekst i vitenarkiv
• Caspersen, Nina Faksvåg; Søyseth, Vidar; Lyngbakken, Magnus Nakrem; Berge, Trygve; Ariansen, Inger Kristine Holtermann & Tveit, Arnljot [Vis alle 8 forfattere av denne artikkelen] (2022). Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study. COPD: Journal of Chronic Obstructive Pulmonary Disease. ISSN 1541-2555. 9(2), s. 165–180. doi: 10.15326/jcopdf.2021.0265. Fulltekst i vitenarkiv
• Ruud, Espen Asak; Stavem, Knut; Geitung, Jonn Terje; Borthne, Arne Sigmund; Søyseth, Vidar & Ashraf, Haseem (2021). Predictors of pneumothorax and chest drainage after percutaneous CT-guided lung biopsy: A prospective study. European Radiology. ISSN 0938-7994. doi: 10.1007/s00330-020-07449-6.
• Søyseth, Vidar; Kononova, Natalia; Neukamm, Anke; Holmedahl, Nils Henrik; Hagve, Tor-Arne & Omland, Torbjørn [Vis alle 7 forfattere av denne artikkelen] (2021). Systemic inflammation induced by exacerbation of COPD or pneumonia in patients with COPD induces cardiac troponin elevation. BMJ Open Respiratory Research. ISSN 2052-4439. 8(1), s. 1–8. doi: 10.1136/bmjresp-2021-000997. Fulltekst i vitenarkiv
• Søyseth, Torunn Stavnes; Dew, Mary Amanda; Samersaw-Lund, May Brit; Haugstad, Gro Killi; Søyseth, Vidar & Malt, Ulrik Fredrik (2020). Coping Patterns and Emotional Distress in Patients With Chronic Obstructive Lung Disease Who Are Undergoing Lung Transplant Evaluation. Progress in transplantation. ISSN 1526-9248. 30(3), s. 228–234. doi: 10.1177/1526924820933817. Fulltekst i vitenarkiv
• Kononova, Natalia; Sikkeland, Liv Ingunn Bjoner; Mahmood, Faiza; Vistnes, Maria; Kongerud, Johny & Einvik, Gunnar [Vis alle 7 forfattere av denne artikkelen] (2019). Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample. BMC Pulmonary Medicine. ISSN 1471-2466. 19. doi: 10.1186/s12890-018-0765-7. Fulltekst i vitenarkiv
• Einvik, Gunnar; Bhatnagar, Rahul; Holmedahl, Nils Henrik; Neukamm, Anke; Omland, Torbjørn & Søyseth, Vidar (2017). Premature Ventricular Complex is More Prevalent During Acute Exacerbated than Stable States of Chronic Obstructive Pulmonary Disease, and Is Related to Cardiac Troponin T. COPD: Journal of Chronic Obstructive Pulmonary Disease. ISSN 1541-2555. 14(3), s. 318–323. doi: 10.1080/15412555.2017.1298085. Fulltekst i vitenarkiv
• Neukamm, Anke; Einvik, Gunnar; Høiseth, Arne Didrik; Søyseth, Vidar; Holmedahl, Nils Henrik & Kononova, Natalia [Vis alle 7 forfattere av denne artikkelen] (2016). The prognostic value of measurement of high-sensitive cardiac troponin T for mortality in a cohort of stable chronic obstructive pulmonary disease patients. BMC Pulmonary Medicine. ISSN 1471-2466. 16(1). doi: 10.1186/s12890-016-0319-9.
• Søyseth, Torunn Stavnes; Lund, May-Brith; Bjørtuft, Øystein; Heldal, Aasta; Søyseth, Vidar & Dew, Mary Amanda [Vis alle 8 forfattere av denne artikkelen] (2016). Psychiatric disorders and psychological distress in patients undergoing evaluation for lung transplantation: a national cohort study. General Hospital Psychiatry. ISSN 0163-8343. 42, s. 67–73. doi: 10.1016/j.genhosppsych.2016.07.001.
• Sikkeland, Liv Ingunn Bjoner; Johnsen, Helle Laier; Riste, Tonje Bøyum; Alexis, Neil E.; Halvorsen, Bente & Søyseth, Vidar [Vis alle 7 forfattere av denne artikkelen] (2016). Sputum neutrophils are elevated in smelter workers, and systemic neutrophils are associated with rapid decline in FEV1. Occupational and Environmental Medicine. ISSN 1351-0711. 73(7), s. 459–466. doi: 10.1136/oemed-2015-103083. Vis sammendrag

  Abstract: Objectives In a previous study on smelter workers we, found significant relationship between exposure to dust and accelerated annual decline in forced expiratory volume in 1 s (FEV1). In this cross-sectional study at the end of a follow-up, we aimed to investigate the possible association between annual decline in FEV1 and markers of airways, and systemic inflammation in smelter workers. Methods: Employees (n=76 (27 current smokers)) who had been part of a longitudinal study (9–13 years) that included spirometry (>6 measurements) and respiratory questionnaires, performed induced sputum, exhaled NO and had blood drawn. Participants with annual decline in FEV1≥45 mL were compared with participants with annual decline <45 mL; also 26 non-exposed controls were included. Results: Compared with non-exposed controls, smelter workers demonstrated a significantly increased percentage of neutrophils (mean (SD)) (57% (17) vs 31% (15)) and matrix metalloproteinases 8 (MMP-8) levels in sputum, and MMP-9, surfactant protein D (SpD) and transforming growth factor β (TGFb) levels in blood. A significant association in FEV1≥45 mL was found for blood neutrophils when controlling for smoking habits (OR=1.7 (95% CI 1.0 to 2.8), p=0.045). Airway and blood protein markers were not associated with annual decline in FEV1. Conclusions: All workers displayed airway and systemic inflammation characterised by increased levels of neutrophils and MMP-8 in sputum, and MMP-9, SpD and TGFβ in blood compared with non-exposed controls. Blood neutrophils in particular were significantly elevated in those workers with the most rapid decline in lung function. A similar observation was not seen with airway neutrophils. In the present study, we were able to identify systemic but not airway inflammatory markers that can predict increased decline in FEV1 in smelter workers.

• Søyseth, Vidar; Henneberger, Paul K; Einvik, Gunnar; Virji, Mohammed Abbas; Bakke, Berit & Kongerud, Johny (2016). Annual decline in forced expiratory volume is steeper in aluminum potroom workers than in workers without exposure to potroom fumes. American Journal of Industrial Medicine. ISSN 0271-3586. 59(4), s. 322–329. doi: 10.1002/ajim.22570. Vis sammendrag

  Background: Aluminum potroom exposure is associated with increased mortality of COPD but the association between potroom exposure and annual decline in lung function is unknown. We have measured lung volumes annually using spirometry from 1986 to 1996. The objective was to compare annual decline in forced expiratory volume in 1 s (dFEV1) and forced vital capacity (dFVC). Methods: The number of aluminum potroom workers was 4,546 (81% males) and the number of workers in the reference group was 651 (76% males). The number of spirometries in the index group and the references were 24,060 and 2,243, respectively. Results: After adjustment for confounders, the difference in dFEV1 and dFVC between the index and reference groups were 13.5 (P < 0.001) and −8.0 (P = 0.060) ml/year. Conclusion: Aluminum potroom operators have increased annual decline in FEV1 relative to a comparable group with non‐exposure to potroom fumes and gases.

• Høiseth, Arne Didrik; Brynildsen, Jon; Hagve, Tor-Arne; Christensen, Geir Arve; Søyseth, Vidar & Omland, Torbjørn [Vis alle 7 forfattere av denne artikkelen] (2016). The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: Data from the Akershus cardiac examination (ACE) 2 study. Biomarkers. ISSN 1354-750X. 21(2), s. 173–179. doi: 10.3109/1354750X.2015.1126645.
• Søyseth, Vidar; Henneberger, Paul; Virji, Mohammed Abbas; Bakke, Berit & Kongerud, Johny (2015). Construction of a job exposure matrix to dust, fluoride, and polycyclic aromatic hydrocarbons in the Norwegian aluminum industry using prediction models. Annals of Occupational Hygiene. ISSN 0003-4878. 59(9), s. 1106–1121. doi: 10.1093/annhyg/mev069. Vis sammendrag

  Background: The Norwegian aluminum industry developed and implemented a protocol for prospective monitoring of employees’ exposure using personal samplers. We analyzed these data to develop prediction lines to construct a job exposure matrix (JEM) for the period 1986–1995. Methods: The protocol for personal monitoring of exposure was implemented in all seven Norwegian aluminum plants in 1986 and continued until 1995. Personal samplers were used to collect total dust, fluorides, and total polycyclic aromatic hydrocarbons (PAH). In addition, exposure could be categorized according to process, i.e. prebake, Søderberg, and ‘other’. We constructed four-dimensional JEMs characterized by: Plant, Job descriptor, Process, and Year. Totally 8074, 6734, and 3524 measurements were available for dust, fluorides, and PAH, respectively. The data were analyzed using linear mixed models with two-way interactions. The models were assessed using the Akaike criterion (AIC) and unadjusted R2. The significance level was set to 10% (two-sided) for retaining variables in the model. Results: In 1986, the geometric mean (95% confidence interval in parentheses) for total dust, total fluorides, and PAH were 3.18 (0.46–22.2) mg m−3, 0.58 (0.085–4.00) mg m−3, and 33.9 (2.3–504) µg m−3, respectively. During 10 years of follow-up, the exposure to total dust, fluorides, and PAH decreased by 9.2, 11.7, and 14.9% per year, respectively. Each model encompassed from 49 to 72 significant components of the interaction terms. The interaction components were at least as important as the main effects, and 65 to 91% of the significant components of the interaction terms were time-dependent. Conclusion: Our prediction models indicated that exposures were highly time-dependent. We expect that the time-dependent changes in exposure are of major importance for longitudinal studies of health effects in the aluminum industry.

• Søyseth, Vidar; Johnsen, Helle Laier; Henneberger, Paul K. & Kongerud, Johny (2015). Increased decline in pulmonary function among employees in Norwegian smelters reporting work-related asthma-like symptoms. Journal of Occupational and Environmental Medicine. ISSN 1076-2752. 57(9), s. 1004–1008. doi: 10.1097/JOM.0000000000000518. Vis sammendrag

  Objective: To investigate associations between work-related asthma-like symptoms (WASTH) and annual pulmonary function decline among employees of 18 Norwegian smelters. Methods: A 5-year longitudinal study in which WASTH was defined as a combination of dyspnea and wheezing that improved on rest days and vacation. Results: A total of 12,966 spirometry examinations were performed in 3084 employees. Crude annual decline in forced expiratory volume in 1 second (FEV1) (dFEV1) was 32.9 mL/yr (95% confidence interval, 30.5 to 35.3), and crude annual decline in forced vital capacity (FVC) (dFVC) was 40.9 mL/yr (37.8 to 43.9). After adjustment for relevant covariates, employees reporting WASTH showed higher dFEV1 by 16.0 m:/yr (3.4 to 28.6) and higher dFVC by 20.5 mL/yr (6.0 to 35.0) compared with employees not reporting WASTH. Conclusion: Work-related asthma-like symptom was associated with greater annual declines in FEV1 and FVC, indicating a restrictive pattern.

• Søyseth, Vidar; Aaløkken, Trond Mogens; Mynarek, Georg; Naalsund, Anne; Strøm, Erik Heyerdahl & Scott, Helge [Vis alle 7 forfattere av denne artikkelen] (2015). Diagnosis of biopsy verified usual interstitial pneumonia by computed tomography. Respiratory Medicine. ISSN 0954-6111. 109(7), s. 897–903. doi: 10.1016/j.rmed.2015.05.008. Vis sammendrag

  Objective To identify the combination of clinical data and high resolution computed tomography (HRCT) features that best identified biopsy verified usual interstitial pneumonia (UIP). Methods The study included 91 patients with a tentative diagnosis of interstitial lung disease. All underwent clinical investigation, surgical lung biopsy and HRCT. Two independent readers assessed the HRCT images for the extent and pattern of abnormality. On the basis of the biopsy result the patients were categorized in three groups: 1) Usual interstitial pneumonia, 2) Other idiopathic interstitial pneumonias (IIPs) and hypersensitivity pneumonitis and 3) Other interstitial lung diseases. The diagnostic value of HRCT was investigated using likelihood ratio to estimate the post-test probability of UIP. Results We found that UIP was associated with significantly higher scores for reticular pattern and for bronchiectasis than the remaining patients (p < 0.001). Moreover, these scores showed a steeper cranial-caudal increase in patients with histologically verified UIP than in the remaining patients (p < 0.001). UIP was associated with lower scores for ground glass opacities (p < 0.001). Using Bayes theorem and likelihood ratio estimation we found that UIP could be diagnosed with 90% certainty in patients 60 years or older and restrictive pattern in spirometry provided that HRCT demonstrated at least 15% reticular pattern and no ground glass opacities. Conclusion In older patients with a restrictive spirometry in whom HRCT demonstrates a reticular pattern without ground glass opacities surgical lung biopsy is not warranted for the diagnosis of UIP.

• Neukamm, Anke; Høiseth, Arne Didrik; Einvik, Gunnar; Lehmann, Sverre; Hagve, Tor-Arne & Søyseth, Vidar [Vis alle 7 forfattere av denne artikkelen] (2015). Rosuvastatin treatment in stable chronic obstructive pulmonary disease (RODEO): a randomized controlled trial. Journal of Internal Medicine. ISSN 0954-6820. 278(1), s. 59–67. doi: 10.1111/joim.12337.
• Høiseth, Arne Didrik; Neukamm, Anke; Hagve, Tor-Arne; Omland, Torbjørn; Brekke, Pål Haugar & Søyseth, Vidar (2014). The clinical value of serial measurement of high-sensitivity cardiac troponin T in acute exacerbations ofchronic obstructive pulmonary disease. Open heart. ISSN 2053-3624. 1. doi: 10.1136/openhrt-2013-000001.
• Kongerud, Johny & Søyseth, Vidar (2014). Respiratory disorders in aluminum smelter workers. Journal of Occupational and Environmental Medicine. ISSN 1076-2752. 56(5), s. S60–S70. doi: 10.1097/JOM.0000000000000105.
• Søyseth, Vidar; Johnsen, Helle Laier & Kongerud, Johny (2013). Respiratory hazards of metal smelting. Current opinion in pulmonary medicine. ISSN 1070-5287. 19(2), s. 158–162. doi: 10.1097/MCP.0b013e32835ceeae. Vis sammendrag

  Purpose of review: The metal smelting industry is an important industry in the majority of countries in the world and employs millions of workers. In most of the production types, a variety of pollutants are emitted into the workplace atmosphere. Some of these pollutants have sensitizing properties, whereas other act as irritants in the respiratory tract. This review will explore the recent studies (2010–2012) which address the impact of exposure to pollutants in the smelting industry on nonmalignant respiratory disorders. Recent findings: The association between different respiratory symptoms as well as pulmonary function and the level of exposure to different agents has been investigated. Likewise, the effect of primary prevention (exposure reduction) and secondary prevention (relocation) has been studied. Finally, the association between the incidence of community-acquired pneumonia and exposure to pollutants encountered at work in the smelting industry and the results from mortality studies are reported. Summary: It appears that exposure to emissions of pollutants in the smelting industry is associated with respiratory symptoms, including asthma, lung function decline and chronic obstructive pulmonary disease, depending on the type of production. Moreover, it is possible that these exposures may enhance the risk of infectious pneumonia.

• Høiseth, Arne Didrik; Omland, Torbjørn; Karlsson, Bo Daniel; Brekke, Pål Haugar & Søyseth, Vidar (2013). Standardized evaluation of lung congestion during COPD exacerbation better identifies patients at risk of dying. The International Journal of Chronic Obstructive Pulmonary Disease. ISSN 1176-9106. 8, s. 621–629. doi: 10.2147/COPD.S52854.
• Johnsen, Helle Laier; Bugge, Merete Drevvatne; Føreland, Solveig; Kjuus, Helge; Kongerud, Johny & Søyseth, Vidar (2013). Dust exposure is associated with increased lung function loss among workers in the Norwegian silicon carbide industry. Occupational and Environmental Medicine. ISSN 1351-0711. 70(11), s. 803–809. doi: 10.1136/oemed-2012-101068. Vis sammendrag

  Objectives: To investigate the relationship between dust exposure and annual change in lung function among employees in Norwegian silicon carbide (SiC) plants using a quantitative job exposure matrix (JEM) regarding total dust. Methods: All employees, 20–55 years of age by inclusion (n=456), were examined annually for up to 5 years (1499 examinations). Spirometry was performed at each examination, and a questionnaire encompassing questions of respiratory symptoms, smoking status, job and smoking history, and present job held was completed. A JEM was constructed based on 1970 personal total dust exposure measurements collected during the study period. The association between lung function and total dust exposure was investigated using linear mixed models. Results: The annual change in forced expiratory volume (FEV) in one second per squared height, FEV1/height2, per mg/m3 increase in dust exposure was −2.3 (95% CI −3.8 to −0.79) (mL/m2)×year−1. In an employee of average height (1.79 m) and exposure (1.4 mg/m3) the estimated contribution to the annual change in FEV1 associated with dust was 10.4 mL/year. The annual change in FEV1/height2 in current, compared with non-smokers was −1.9 (−7.2 to 3.4) (mL/m2)×year−1. The estimated overall annual decline in FEV1 among current and non-smokers in the highest exposed group was −91.2 (−124.3 to −58.1) (mL/m2)×year−1 and −49.0 (−80.2 to −17.8) (mL/m2)×year−1, respectively. Conclusions: Dust exposure, expressed by a quantitative JEM, was found to be associated with an increased yearly decline in FEV1 in employees of Norwegian SiC plants.

• Vistnes, Maria; Høiseth, Arne Didrik; Røsjø, Helge; Nygård, Ståle; Pettersen, Eirik & Søyseth, Vidar [Vis alle 9 forfattere av denne artikkelen] (2013). Lack of pro-inflammatory cytokine mobilization predicts poor prognosis in patients with acute heart failure. Cytokine. ISSN 1043-4666. 61(3), s. 962–969. doi: 10.1016/j.cyto.2013.01.006.
• Søyseth, Vidar; Bhatnagar, Rahul; Holmedahl, Nils Henrik; Neukamm, Anke; Høiseth, Arne Didrik & Hagve, Tor-Arne [Vis alle 8 forfattere av denne artikkelen] (2013). Acute exacerbation of COPD is associated with fourfold elevation of cardiac troponin T. Heart. ISSN 1355-6037. 99(2), s. 122–126. doi: 10.1136/heartjnl-2012-302685.
• Neukamm, Anke; Høiseth, Arne Didrik; Hagve, Tor-Arne; Søyseth, Vidar & Omland, Torbjørn (2013). High-sensitivity cardiac troponin T levels are increased in stable COPD. Heart. ISSN 1355-6037. 99(6), s. 382–387. doi: 10.1136/heartjnl-2012-303429.
• Høiseth, Arne Didrik; Omland, Torbjørn; Hagve, Tor-Arne; Brekke, Pål Haugar & Søyseth, Vidar (2012). NT-proBNP independently predicts long term mortality after acute exacerbation of COPD - a prospective cohort study. Respiratory Research. ISSN 1465-9921. 13(97). doi: 10.1186/1465-9921-13-97.
• Søyseth, Vidar; Johnsen, Helle Laier; Henneberger, Paul K. & Kongerud, Johny (2012). The incidence of work-related asthma-like symptoms and dust exposure in Norwegian smelters. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 185(12), s. 1280–1285. doi: 10.1164/rccm.201110-1809OC. Vis sammendrag

  Rationale: The prevalence of respiratory symptoms amongemployees in smelters is positively associated with dust exposure. Objectives: To investigate the association between the incidence of work-related asthma-like symptoms (WASTH) and dust exposure. Methods: All the employees were invited to participate in a 5-year longitudinal study. The outcome of WASTH was defined as the combination of dyspnea and wheezing improving on rest days or vacation in an individual who had no asthma previously. Information about smoking and occupational status was obtained from a questionnaire. A job exposure matrix of total dust was developed. Multivariate data analyses were performed using Cox regression. Measurements and Main Results: The total follow-up time of the employees (n ¼ 2,476) was 8,469 years, and the median follow-up time for participantswas 4.0 years.During the follow-up, 91employees developed WASTH, and the corresponding incidence rate for WASTH per 1,000 person-years was 8.9 (7.3–10.9) (95% confidence interval in parentheses). The risk ratio ofWASTH increased significantly (P ¼ 0.0001)with dust exposure in the middle andhighcategories (1.0–2.9 and>3.0mg/m3). Stratifiedanalyses showedthat theeffect ofcurrent dust exposure varied with both previous exposure (PE) to dust and fumes (P ¼ 0.006) and airflow limitation (AFL) (P ¼ 0.033). The final analyses showedthat the risk ratios forWASTHper 1mg/m3 increase in current dust exposure were 1.1 (0.93–1.2), 1.4 (1.1–1.8), 1.6 (1.1–2.3), and 1.9 (1.2–3.0) for the categories (PE1/AFL2), (PE2/AFL2), (PE1/ AFL1, and (PE2/AFL1). Conclusions: In conclusion, dust exposure was associated with an increased incidence of WASTH. Keywords: work-related asthma-like symptoms; incidence; dust exposure

• Aaløkken, Trond Mogens; Naalsund, Anne; Mynarek, Georg; Berstad, Audun Elnæs; Solberg, Steinar & Strøm, Erik Heyerdahl [Vis alle 9 forfattere av denne artikkelen] (2012). Diagnostic accuracy of computed tomography and histopathology in the diagnosis of usual interstitial pneumonia. Acta Radiologica. ISSN 0284-1851. 53(3), s. 296–302. doi: 10.1258/ar.2011.110482.
• Søyseth, Vidar; Johnsen, Helle Laier; Bugge, Merete Drevvatne & Kongerud, Johny (2012). The association between symptoms and exposure is stronger in dropouts than in non-dropouts among employees in Norwegian smelters: a five-year follow-up study. International Archives of Occupational and Environmental Health. ISSN 0340-0131. 85(1), s. 27–33. doi: 10.1007/s00420-011-0631-x. Vis sammendrag

  Purpose: We have investigated the association between respiratory symptoms and dust exposure among employees in 18 Norwegian smelters using a longitudinal design. Methods: All employees (N = 3,084) were examined annually for 5 years (12,996 health examinations). At each examination, the subjects reported if they had respiratory symptoms, coded as 1 (yes) or 0 (no), on a respiratory questionnaire. Symptom score was constructed as the sum of symptoms (0–5). Full-time workers in the production line were classified as line operators; subjects never exposed in the production line were regarded as non-exposed. The remaining individuals were classified as non-line operators. A job-exposure matrix regarding dust exposure was also available. Analyses of repeated measurements were performed using generalised linear mixed model with log-link (Poisson regression). Adjustments were made for overdispersion. Results: The mean age at inclusion was 39.0 years, and 89% were men. The median dust exposure in tertiles 1–3 was 0.19, 1.76 and 3.47 mg/m3. The longitudinal analyses showed that the association between symptoms-score ratio (SSR) and job category was significantly stronger in dropouts compared with non-dropouts (p = 0.01). Among the dropouts, SSR was 1.61 (95% confidence interval: 1.27–2.05) and 1.39 (1.09–1.77) in line operators and non-line operators compared with non-exposed employees, respectively. The corresponding SSR for subjects who completed the study was 1.13 (1.01–1.27) and 1.12 (1.00–1.26), respectively. Similarly, among the dropouts, the SSR between the second and the first tertile was 1.28 (1.05–1.55) and 1.37 (1.13–1.66) between the third tertile and the first tertile. Conclusions: Line operators had more respiratory symptoms than non-exposed employees. This effect was significantly stronger in dropouts than in those who continued their jobs, indicating that there is a selection of subjects without respiratory symptoms in this industry.

• Høiseth, Arne Didrik; Omland, Torbjørn; Hagve, Tor-Arne; Brekke, Pål Haugar & Søyseth, Vidar (2012). Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study. BMC Pulmonary Medicine. ISSN 1471-2466. 12(22). doi: 10.1186/1471-2466-12-22.
• Høiseth, Arne Didrik; Neukamm, Anke; Karlsson, Bo Daniel; Omland, Torbjørn; Brekke, Pål Haugar & Søyseth, Vidar (2011). Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease. Thorax. ISSN 0040-6376. 66(9), s. 775–781. doi: 10.1136/thx.2010.153122.
• Søyseth, Vidar; Johnsen, Helle Laier; Drevvatne Bugge, Merete; Hetland, Siri & Kongerud, Johny (2011). Incidence of Airflow Limitation Among Employees in Norwegian Smelters. American Journal of Industrial Medicine. ISSN 0271-3586. 54(9), s. 707–713. doi: 10.1002/ajim.20946. Vis sammendrag

  We have investigated the association between the incidence of airflow limitation and occupational exposure. The employees (n = 3,924) were investigated annually during five years (n = 16,570) using spirometry. Exposure was classified using job category and a job exposure matrix. Airflow limitation was expressed using two indices: (i) as forced expiratory volume in one second/force vital capacity (FEV1/FVC) <0.7 and (ii) lower limit of normal (LLN). The incidence of airflow limitation was 21.2/1000 years−1 and 15.1/1000 years−1 using the fixed limit (0.7) and the LLN criterion, respectively. We found a dose–response relationship between the incidence of airflow limitation and tobacco consumption and with job‐category in non‐smokers. The associations between airflow limitation and covariates were independent of how airflow limitation was defined. The incidence of airflow limitation defined as FEVl/FVC <0.7 yielded higher incidence rates of airflow limitation than LLN. We found a significant association between the incidence of airflow limitation and occupational exposure in non‐smokers.

• Søyseth, Vidar; Johnsen, Helle Laier; Drevvatne Bugge, Merete; Hetland, Siri & Kongerud, Johny (2011). Prevalence of airflow limitation among employees in Norwegian smelters: a longitudinal study. Occupational and Environmental Medicine. ISSN 1351-0711. 68(1), s. 24–29. doi: 10.1136/oem.2009.049452. Vis sammendrag

  Aims To investigate the association between airflow limitation and occupational exposure and to compare a fixed limit with an age adjusted limit for airflow limitation. Methods 3924 employees in 24 Norwegian smelters and related workplaces were investigated annually over 5 years (n=16 570) using spirometry and a respiratory questionnaire on smoking habits and job category. Employees working full time on the production line were classified as line operators; subjects who never worked on the production line were regarded as non-exposed. A job exposure matrix (JEM) was available in most smelters. Airflow limitation was expressed as (i) forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC ratio) <0.7 and (ii) FEV1/FVC ratio less than the lower limit of normal (LLN). Longitudinal analyses on the prevalence of airflow limitation were performed using a generalised linear mixed model. Results The prevalence of airflow limitation was stable during follow-up. The OR of airflow limitation during follow-up was 1.24 (95% CI 1.03 to 1.50) in line operators compared with unexposed subjects for FEV1/FVC ratio <0.7 and 1.44 (1.14 to 1.81) for FEV1/FVC ratio <LLN. A dose–response relationship was also found between prevalence of airflow limitation and dust exposure. The annual decline in FEV1 was −77.5 (SD 99.9) ml/year in subjects with FEV1/FVC ratio <0.7 and −83.8 (114.2) ml/year in subjects with FEV1/FVC ratio <LLN. Conclusion Prevalence of airflow limitation was higher in exposed than non-exposed employees. Both the FEV1/FVC ratio <0.7 and FEV1/FVC ratio <LLN identify subjects with accelerated annual decline in FEV1.

• Søyseth, Torunn Stavnes; Søyseth, Vidar & Mengshoel, Anne Marit (2011). Pain reduction after a multidisiplinary education programme for elderly women with osteoporosis - a pilot study. Fysioterapeuten. ISSN 0016-3384. s. 16–21.
• Johnsen, Helle Laier; Hetland, Siri M.; Saltyte-Benth, Jurate; Kongerud, Johny & Søyseth, Vidar (2010). Dust Exposure Assessed by a Job Exposure Matrix Is Associated with Increased Annual Decline in FEV1 A 5-year Prospective Study of Employees in Norwegian Smelters. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 181(11), s. 1234–1240. doi: 10.1164/rccm.200809-1381OC. Vis sammendrag

  Rationale: The relationship between dust exposure and annual decline in lung function among employees in the smelting industry is unknown. Objectives: The aim of the study was to investigate the relationship between annual change in lung function and occupational dust exposure among workers in 15 Norwegian smelters. Methods: All employees (n = 2,620) were examined annually for 5 years (11,335 health examinations). At each examination spirometry was performed and a respiratory questionnaire was completed. The smelters were grouped as follows: (1) ferrosilicon alloys (FeSi) and silicon metal (Si-metal); and (2) silicon manganese (SiMn), ferromanganese (FeMn), and ferrochromium (FeCr). A job exposure matrix was available on the basis of 2,619 personal dust exposure measurements. The association between lung function expressed as FEV1 and FVC per squared height (height2) and dust exposure was investigated using multivariate linear mixed model analyses. Measurements and Main Results: The annual change in FEV1/height2 (δFEV1) related to dust exposure in the FeSi/Si-metal and SiMn/FeMn/FeCr smelters was –0.42 (95% confidence interval, −0.95 to 0.11) and −1.1 (−2.1 to −0.12) (ml/m2) × (mg/m3)−1 × year−1, respectively. The annual decline in FEV1/height2 was 1.6 ml/m2 (0.15 to 3.1) steeper in smokers than in nonsmokers. The median geometric mean of the time-weighted dust exposure concentration levels of the employees was 2.3 mg/m3 in the FeSi/Si-metal smelters and 1.6 mg/m3 in the SiMn/FeMn/FeCr smelters. Among nonsmokers, δFEV1 was −0.86 (−1.6 to −0.10) and –1.1 (−2.5 to 0.25) (ml/m2) × (mg/m3)−1 × year−1 in the FeSi/Si-metal and SiMn/FeMn/FeCr smelters, respectively. Thus, for a 1.80 m tall employee the annual decline in FEV1 associated with average dust exposure was 5.7 ml/year in the SiMn/FeMn/FeCr smelters, and 6.4 ml/year for a nonsmoker in the FeSi/Si-metal smelters. Conclusions: In all smelters combined, the annual change in FEV1 was negatively associated with increasing dust exposure. This association was also significant among workers in SiMn/FeMn/FeCr smelters and among nonsmokers in the FeSi/Si-metal smelters.

• Aaløkken, Trond Mogens; Lilleby, Vibke; Søyseth, Vidar; Mynarek, Georg; Pripp, Are Hugo & Johansen, Bjørn [Vis alle 8 forfattere av denne artikkelen] (2009). Chest Abnormalities in Juvenile-Onset Mixed Connective Tissue Disease: Assessment with High-Resolution Computed Tomography and Pulmonary Function Tests. Acta Radiologica. ISSN 0284-1851. 50(4), s. 430–436. doi: 10.1080/02841850902787677.
• Søyseth, Vidar; Johnsen, Helle Laier; Bugge, M; Hetland, SM & Kongerud, Johny (2009). The association between symptoms and dust exposure among employees in the Norwegian smelting industry. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 34.
• Brekke, Pål Haugar; Omland, Torbjørn; Holmedal, S.H.; Smith, Pål & Søyseth, Vidar (2009). Determinants of cardiac troponin T elevation in COPD exacerbation - a cross-sectional study. BMC Pulmonary Medicine. ISSN 1471-2466. 9(35). doi: 10.1186/1471-2466-9-35.
• Johnsen, Helle Laier; Søyseth, Vidar; Hetland, SM; Saltyte-Benth, Jurate & Kongerud, Johny (2008). Production of silicon alloys is associated with respiratory symptoms among employees in Norwegian smelters. International Archives of Occupational and Environmental Health. ISSN 0340-0131. 81, s. 451–459. doi: 10.1007/s00420-007-0237-5. Vis sammendrag

  Objectives: To develop a qualitative exposure classification of employees in Norwegian smelters and to investigate the relationship between respiratory symptoms and occupational exposure using this classification. Methods: The 3,924 participants completed a standardised questionnaire including questions of respiratory symptoms, familial asthma, allergy, doctor-diagnosed asthma, smoking habits, previous exposure and occupation. The employees were classified according to their current job function: (1) line operators were employed full time on the production line, (2) non-exposed employees did not work in production, (3) the remaining employees were classified as non-line operators. The association between the prevalence of respiratory symptoms and job category was examined using multivariate logistic regression. Results: The mean age of the participants was 38.6 years (standard deviation 9.2 years), 88.5% were males. The odds ratios (OR) (95% confidence intervals in parenthesis) for dyspnoea, cough and phlegm regarding previous exposure compared with no previous exposure were 1.4 (1.1–1.7), 1.4 (1.2–1.8) and 1.3 (1.0–1.7), respectively. The OR in line operators compared with non-exposed employees was 1.2 (0.9–1.7) for dyspnoea, 1.3 (1.0–1.8) for cough and 1.9 (1.4–2.7) for phlegm. The OR for respiratory symptoms was higher in relation to previous exposure than current job function except for phlegm. Conclusion: In Norwegian smelters respiratory symptoms appear to be positively related to both current job function and previous exposure. Previous exposure appears to be more important than current job function.

• Søyseth, Vidar; Johnsen, Helle Laier & Kongerud, Johny (2008). Prediction of dropout from respiratory symptoms and airflow limitation in a longitudinal respiratory study. Scandinavian Journal of Work, Environment and Health. ISSN 0355-3140. 34, s. 224–229.
• Johnsen, Helle Laier; Hetland, SM; Saltyte-Benth, Jurate; Kongerud, Johny & Søyseth, Vidar (2008). Quantitative and Qualitative Assessment of Exposure among Employees in Norwegian Smelters. Annals of Occupational Hygiene. ISSN 0003-4878. 52(7), s. 623–633. doi: 10.1093/annhyg/men046.
• Johnsen, Helle Laier; Kongerud, Johny; Hetland, SM; Saltyte-Benth, Jurate & Søyseth, Vidar (2008). Decreased lung function among employees at Norwegian smelters. American Journal of Industrial Medicine. ISSN 0271-3586. 51(4), s. 296–306. doi: 10.1002/ajim.20557.
• Brekke, Pål Haugar; Omland, Torbjørn; Smith, Pål & Søyseth, Vidar (2008). Underdiagnosis of myocardial infartion in COPD - cardiac infarction injury score (CIIS) in patients hospitalised for COPD exacerbation. Respiratory Medicine. ISSN 0954-6111. 102, s. 1243–1247. doi: 10.1016/j.rmed.2008.04.010.
• Brekke, Pål Haugar; Omland, Torbjørn; Holmedal, S.H.; Smith, Pål & Søyseth, Vidar (2008). Troponin T elevation and long-term mortality after chronic obstructive pulmonary disease exacerbation. European Respiratory Journal. ISSN 0903-1936. 31, s. 563–570. doi: 10.1183/09031936.00015807.
• Frostad, Anne; Søyseth, Vidar; Haldorsen, Tor; Andersen, Aage & Gulsvik, Amund (2008). Impact of respiratory symptoms on lung cancer: 30-year follow-up of an urban population. Lung Cancer. ISSN 0169-5002. 60(1), s. 22–30. doi: 10.1016/j.lungcan.2007.09.002.
• Søyseth, Vidar; Saltyte-Benth, Jurate & Stavem, Knut (2007). The association between hospitalisation for pneumonia and the diagnosis of lung cancer. Lung Cancer. ISSN 0169-5002. 57, s. 152–158. doi: 10.1016/j.lungcan.2007.02.022.
• Søyseth, Vidar; Johnsen, Helle Laier; Saltyte-Benth, Jurate; Hetland, SM & Kongerud, Johny (2007). Production of silicon metal and alloys is associated with accelerated decline in lung function - A 5-year prospective study among 3924 employees in Norwegian smelters. Journal of Occupational and Environmental Medicine. ISSN 1076-2752. 49. doi: 10.1097/JOM.0b013e3181452830.
• Søyseth, Vidar; Brekke, Pål Haugar; Smith, Pål & Omland, Torbjørn (2007). Statin use is associated with reduced mortality in COPD. European Respiratory Journal. ISSN 0903-1936. 29, s. 279–283. doi: 10.1183/09031936.00106406.
• Frostad, Anne; Søyseth, Vidar; Haldorsen, Tor; Andersen, Aage & Gulsvik, Amund (2007). Respiratory symptoms and long-term cardiovascular mortality. Respiratory Medicine. ISSN 0954-6111. s. 2289–2296. doi: 10.1016/j.rmed.2007.06.023.
• Frostad, Anne; Søyseth, Vidar; Andersen, Aage & Gulsvik, Amund (2006). Respiratory symptoms as predictors of all-cause mortality in an urban community: a 30-year follow-up. Journal of Internal Medicine. ISSN 0954-6820. 259(5), s. 520–529 . doi: 10.1111/j.1365-2796.2006.01631.x.
• Frostad, Anne; Søyseth, Vidar; Haldorsen, Tor; Andersen, Aage & Gulsvik, Amund (2006). Respiratory symptoms and 30 year mortality from obstructive lung disease and pneumonia. Thorax. ISSN 0040-6376. 61(11), s. 951–956. doi: 10.1136/thx.2006.059436.
• Søyseth, Vidar (2003). Nasjonal lungekreftdatabase i Norge. Lungeforum. ISSN 0803-4079. s. 16–17.
• Søyseth, Vidar; Boe, Jacob & Kongerud, Johny (1997). Relation between decline in FEV1 and exposure to dust and tobacco smoke in aluminium potroom workers. Occupational and Environmental Medicine. ISSN 1351-0711. 54(1), s. 27–31.
• Nystad, Wenche; Søyseth, Vidar & Magnus, Per (1997). Forekomsten av astma blant skolebarn i Norge i perioden 1985-94. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 117, s. 644–647.
• Søyseth, Vidar; Kongerud, Johny & Boe, Jacob (1996). Increased variability in bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms. Journal of Occupational and Environmental Medicine. ISSN 1076-2752. 38, s. 66–69.
• Søyseth, Vidar; Kongerud, Johny & Boe, Jacob (1996). Allergen sensitization and exposure to irritants in infancy. Allergy. European Journal of Allergy and Clinical Immunology. ISSN 0105-4538. 51, s. 719–723.

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• Søyseth, Vidar (2017). Var kols forklaringen? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(18), s. 1394–1395. doi: 10.4045/tidsskr.17.0772.
• Søyseth, Torunn Stavnes; Lund, MB; Haugstad, Gro Killi; Bjørtuft, Øystein; Søyseth, Vidar & Malt, Ulrik Fredrik (2016). Significant Associations between emotional coping strategies and psychological distress- a national cohort study of potential lung transplant candidates.
• Søyseth, Torunn Stavnes; Haugstad, Gro Killi; Bjørtuft, Øystein; Lund, May Brit; Søyseth, Vidar & Malt, Ulrik Fredrik (2015). Psychological distress in Potential Lung Tranplant Candidates: A National Cohort Study.
• Neukamm, Anke; Høiseth, Arne Didrik; Einvik, Gunnar; Hagve, Tor-Arne; Lehmann, Sverre & Søyseth, Vidar [Vis alle 7 forfattere av denne artikkelen] (2014). Effect Of Rosuvastatin Treatment In Stable COPD (RODEO) .
• Neukamm, Anke; Høiseth, Arne Didrik; Søyseth, Vidar & Omland, Torbjørn (2014). The authors’ reply. Heart. ISSN 1355-6037.
• Høiseth, Arne Didrik; Brynildsen, Jon; Hagve, Tor-Arne; Christensen, Geir Arve; Søyseth, Vidar & Omland, Torbjørn [Vis alle 7 forfattere av denne artikkelen] (2013). hs-cTnT levels in COPD exacerbation predict survival independently of clinical heart failure: data from the Akershus Cardiac Examination 2 (ACE2) study. European Heart Journal. ISSN 0195-668X. 34. doi: 10.1093/eurheartj/eht310.P5755.
• Neukamm, Anke; Holmedahl, Nils Henrik; Einvik, Gunnar; Hagve, Tor-Arne; Somers, Virend K. & Søyseth, Vidar [Vis alle 7 forfattere av denne artikkelen] (2013). Cardiac troponin T levels increase overnight in patients with stable chronic obstructive pulmonary disease .
• Neukamm, Anke; Søyseth, Vidar & Omland, Torbjørn (2013). Raised troponin levels in COPD: a possible mechanism Reply. Heart. ISSN 1355-6037. 99(12). doi: 10.1136/heartjnl-2013-303662.
• Søyseth, Vidar; Johnsen, Helle Laier & Kongerud, Johny (2012). Merchant seafaring: a changing and hazardous occupation Response. Occupational and Environmental Medicine. ISSN 1351-0711. 69(9), s. 690–690. doi: 10.1136/oemed-2012-100695.
• Søyseth, Torunn Stavnes; Lund, May Britt; Heldal, Aasta; Bjørtuft, Øystein; Søyseth, Vidar & Haugstad, Gro Killi [Vis alle 7 forfattere av denne artikkelen] (2012). Coping Strategies in patients awaiting lung transplantation.
• Søyseth, Torunn Stavnes; Lund, May Britt; Heldal, Aasta; Bjortuft, Øystein; Søyseth, Vidar & Haugstad, Gro Killi (2012). Mental Health and bodily pain in patients awaiting lung transplantation. Conclusion: The strong associations between MH and VT and BP may be of clinical relevance. The highly significant differences in PF between COPD and fibrosis may be of clinical importance in patients awaiting lung transplantation.
• Søyseth, Torunn Stavnes; Heldal, Aasta; Haugstad, Gro Killi; Søyseth, Vidar; Bjørtuft, Øystein & Lund, May Brit (2011). Anxiety, depression and coping in patients awaiting lung transplantation.
• Neukamm, Anke; Høiseth, Arne Didrik; Hagve, Tor-Arne; Søyseth, Vidar & Omland, Torbjørn (2011). High sensitivity cardiac troponin T levels are increased in stable COPD (Poster).
• Søyseth, Vidar; Johnsen, Helle Laier; Bugge, M & Kongerud, Johny (2009). Prevalence and incidence of airflow limitation among employees in Norwegian smelters.
• Sjaaheim, T.; Kongerud, Johny & Søyseth, Vidar (2003). Work-related asthmatic symptoms in aluminium potroom workers are associated with increased blood eosinophils. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X.
• Søyseth, Vidar; Boe, Jacob & Kongerud, Johny (1996). Fall i FEV1 og eksponering for støv og tobakk hos elektrolyseoperatører i aluminiumsindustrien.
• Neukamm, Anke; Omland, Torbjørn & Søyseth, Vidar (2015). Cardiovascular comorbidity in chronic obstructive pulmonary disase: Biomarkers, vascular function and effects of statin treatment. Akademika forlag. ISSN 9788283331370.
• Høiseth, Arne Didrik; Søyseth, Vidar; Omland, Torbjørn & Brekke, Pål Haugar (2013). Myocardial injury and stress during acute exacerbation of chronic obstructive pulmonary disease. A prospective cohort study. Akademika forlag. ISSN 978-82-8264-752-6.
• Brekke, Pål Haugar & Søyseth, Vidar (2010). Myocardial injury in patients hospitalised for exacerbation of chronic obstructive pulmonary disease. Unipub forlag. ISSN 978-82-8072-587-5.

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