This year’s meeting is organized by the Laboratory for Molecular Infection Medicine Sweden (MIMS). It brings together mainly the group leaders, postdoctoral researchers, and PhD students of the Nordic EMBL Partnership for Molecular Medicine with researchers from EMBL and its broader network to discuss their research, develop new ideas and initiate new projects.
Scientific Programme
Day 1 - Tuesday 22 September 2020 |
|
| 09:00-11:00 | Nordic EMBL Partnership Steering Group Meeting |
| 09:00-11:00 | Young Investigator Workshop – Personal effectiveness: self-leadership and time management Sarah Blackford, BioScience Careers, Germany |
| 11:00-12:00 | Nordic EMBL Administrator Meeting - Part I |
| 12:00-12:30 | Break |
| 12:30-13:20 | Welcome and Opening |
| 12:30-12:40 | Welcome by Hans Adolfsson on behalf of Umeå University |
| 12:40-12:50 | Welcome by Poul Nissen and update on the Partnership |
| 12:50-13:00 | Welcome by Oliver Billker on behalf of MIMS and technical details |
| 13:00-13:20 | Welcome and Updates from EMBL by Edith Heard |
|
13:30-17:15 |
Session 1 - From simple to complex disease models Chair: Oliver Billker, MIMS |
| 13:30-14:05 | Keynote lecture - Human Cell Atlas: Mapping the human body one cell at a time Sarah Teichmann, Wellcome Sanger Institute, United Kingdom |
| 14:15-14:30 |
The multimodal Platynereis cell type atlas Detlev Arendt, EMBL Heidelberg |
| 14:30-14:35 |
Investigating cell type-specific gene expression across developmental stages in the prenatal human cerebral cortex Mari Niemi, FIMM |
| 14:35-14:50 | Molecular views into cellular functions by in-cell cryo-electron tomography Julia Mahamid, EMBL Heidelberg |
| 14:50-15:20 | Break/Poster Session I |
| 15:20-15:25 | NCMM Update by Janna Saarela |
| 15:25-15:40 |
Centromere – a megadalton protein-DNA complex ensuring genomic integrity Nikolina Sekulic, NCMM |
| 15:40-15:55 |
Cryo-EM studies of membrane transporter systems in brain Poul Nissen, DANDRITE |
| 15:55-16:00 |
Cryo-EM structure of Helicobacter pylori urease with a novel inhibitor in the active site at 2.0 Å resolution Eva Cunha, NCMM |
| 16:00-16:05 |
Identification of the first receptor for the environmental signal ATP in bacteria Sophie Tronnet, MIMS |
| 16:05-16:20 |
Understanding cerebral malaria with in vitro 3D microvascular models Maria Bernabeu, EMBL Barcelona |
| 16:20-16:25 |
High-throughput in vivo screening identifies parasite genes determining parasite-host interactions in malaria infections Ellen Bushell, MIMS |
| 16:25-16:30 |
Brain slice model of alpha-synucleinopathies points to role of phosphorylation and strains in Parkinson’s disease and Multiple System Atrophy Nanna Møller Jensen, DANDRITE |
| 16:30-16:45 |
Mechanistic analysis in the omics era Johan Henriksson, MIMS |
| 16:45-17:15 | Summary and Poster Session I continued |
Day 2 - Wednesday 23 September 2020 |
|
| 10:00-12:00 | Special event - Opening science to benefit scientists and society and Panel Discussion Nonia Pariente, Editor-in-Chief, PLOS Biology, United Kingdom Chair: Nonia Pariente Panelists: Theodore Bloom, BMJ, United Kingdom; Ulrich Dirnagl, QUEST&Charité-Universitätsmedizin Berlin, Germany; Tony Ross-Hellauer, Graz University of Technology, Austria; Sophien Kamoun, The Sainsbury Laboratory, United Kingdom; Robert Kiley, Wellcome Trust, United Kingdom |
| 12:00-13:00 | Break |
| 13:00-17:00 | Session 2 - From microbes to mind Chair: Maria Fällman, MIMS |
| 13:00-13:35 |
Keynote lecture - Probing the interface of drugs and microbes Nassos Typas, EMBL Heidelberg, Germany |
| 13:45-14:00 |
Deciphering the evolutionary principles of antimicrobial peptide resistance Balázs Papp, HCEMM-BRC |
| 14:00-14:15 |
Microbes and the intestinal mucosal barrier Björn O. Schröder, MIMS |
| 14:15-14:20 |
RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection Kemal Avican, MIMS |
| 14:20-14:35 |
Identifying gut microbiome contributions to drug metabolism and toxicity Michael Zimmerman, EMBL Heidelberg |
| 14:35-14:40 |
Decoding bacterial cell wall genetics and environmental adaptation through omic-scale peptidoglycan profiling and network analysis Felipe Cava, MIMS |
| 14:40-15:10 | Break/Poster Session II |
| 15:10-15:15 | MIMS Update by Oliver Billker |
| 15:15-15:30 |
How does extreme genome compaction affect structure and function of an ancient conserved RNA-protein complex? Jonas Barandun, MIMS |
| 15:30-15:35 |
Structural basis for bacterial ribosome quality control by RqcH Hiraku Takada, MIMS |
| 15:35-15:40 |
Discovery of novel anti-chlamydial compounds by machine-learning-based predictive modelling Magnus Ölander, MIMS |
| 15:40-15:55 |
The glymphatic system – a brain-wide clearance system Iben Lundgaard, Lund University |
| 15:55-16:00 |
Whole tissue ex vivo imaging sheds light on tropism and neuroinvasion of tick-borne Flavivirus in mouse brain Anna Överby Wernstedt, MIMS |
| 16:00-16:05 |
Inhibited-state structure of human glycine transporter 1 Azadeh Shahsavar, DANDRITE |
| 16:05-16:20 |
Severe sleep disorders are affected and modulated by immune function Hanna Maria Ollila, FIMM |
| 16:30-17:00 | Summary and Poster Session II continued |
Day 3 - Thursday 24 September 2020 |
|
| 14:00-18:00 | Session 3 - From genetic associations to mechanisms Chair: TBA |
| 14:00-14:05 | FIMM Update by Mark Daly |
| 14:05-14:40 |
Keynote lecture - Functional variations in the human genome: Lessons from the transcriptome Tuuli Lappalainen, New York Genome Center & Columbia University, United States |
| 14:45-15:00 |
Estimating the public health impact of genetic variants Andrea Ganna, FIMM |
| 15:00-15:15 |
Open Targets: from genetic associations to mechanisms of drug action – supporting therapeutic hypothesis generation and drug discovery Ellen McDonagh, EMBL-EBI |
| 15:15-15:20 |
Identifying genetic risk variants for Parkinson's disease Mark Denham, DANDRITE |
| 15:20-15:25 |
Orally administered SERCA inhibitor, Cyclopiazonic acid, slows neurodegeneration and increases life span in mouse prion-like spreading model of Parkinson’s disease Cristine Betzer, DANDRITE |
| 15:25-15:30 |
FIMM infrastructure for functional precision medicine Sergey Kuznetsov, FIMM |
| 15:30-15:35 |
Zebrafish larvae carrying a mutation in cacna1d display schizophrenia-like behaviours Nancy Saana Banono, NCMM |
| 15:40-16:10 | Break/Poster Session III |
| 16:10-16:25 |
Megadalton chromatin remodelers: common principles for genome regulation Sebastian Eustermann, EMBL Heidelberg |
| 16:25-16:40 |
Genetic control of somatic mutation patterns in cancer genomes Sebastian Waszak, NCMM |
| 16:40-16:55 |
Functional studies of genetic associations – three stories Eiríkur Steingrímsson, Icelandic University |
| 16:55-17:00 |
Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments Sarang Talwelkar, FIMM |
| 17:00-17:05 | Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancers Jaime Castro-Mondragon, NCMM |
| 17:05-17:20 | Effect of Cas9-fused DNA repair proteins on CRISPR editing outcomes Emma Haapaniemi, NCMM |
| 17:30-18:00 | Summary and Poster Session III continued |
|
|
Day 4 - Friday 25 September 2020 |
| 14:00-17:50 |
Session 4 - From biological to artificial neural networks Chair: Poul Nissen, DANDRITE |
| 14:00-14:35 |
Keynote lecture - From Biological to Artificial Neural Networks: The Case of Face Recognition Winrich Freiwald, The Rockefeller University, United States |
| 14:45-14:50 | Learning action values in biological and artificial systems Duda Kvitsiani, DANDRITE |
| 14:50-15:05 | Female copulation song: eavesdropping on the communication between nervous system and reproductive organs Anne C. von Philipsborn, DANDRITE |
| 15:05-15:20 |
Multiplexed axonal direction selectivity in retinal bipolar cells Keisuke Yonehara, DANDRITE |
| 15:20-15:25 |
High resolution microstructure of the complex of gabaergic synapse with perineuronal net Mikhail Paveliev, DANDRITE |
| 15:25-15:30 | Engineering a dual-optical tool for spectrally distinct optogenetic excitation of neurons Noemie Mermet-Joret, DANDRITE |
| 15:30-15:45 | Machine learning for microscopy image analysis Anna Kreshuk, EMBL Heidelberg |
| 15:45-16:45 | Break/Poster Session IV |
| 16:45-16:50 | DANDRITE Update by Poul Nissen |
| 16:50-17:05 |
Representation learning with deep neural networks to understand somatic mutagenesis in cancers Esa Pitkänen, FIMM |
| 17:05-17:20 |
Large-scale network models to understand gene regulation in healthy and diseased tissues Marieke Kuijjer, NCMM |
| 17:20-17:35 |
The power of multiomics Wolfgang Huber, EMBL Heidelberg |
| 17:35-17:50 | Highlights and Closing remarks |
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Wednesday 30 September 2020 |
| 10:00-12:00 | Nordic EMBL Administrators Meeting - Part II |