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Abstract
Probing the functional effects of genetic variation at enhancers with 3D genomics
Over the last decade, our team has studied enhancer-promoter communication in multiple human systems, capitalising on high-resolution Capture Hi-C. Recently, we have developed a miniaturised version of this assay and evolved the computational tools for Capture Hi-C data analysis and integration with population genetic data. I will present our work using these technologies to (a) leverage natural genetic variation to functionally dissect the relationship between the activity and connectivity of enhancers and (b) link disease-associated variants with target genes in a rare cell type, Type 3 Innate Lymphoid Cells, leading to the identification of a surprising gene candidate for Crohn's disease with a novel function in these cells.
Meet the speaker
If you wish to meet and discuss with Dr. Mikhail Spivakov on Monday Nov. 27th, you are welcome to book a time slot on jotform
About the seminar series
Once a month, NCMM invites international guest speakers to present on topics within molecular life science and medicine. The seminar is open to all, with no registration needed. Tea, coffee and a simple lunch will be served before the start of the seminar.