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Abstract
Data- and AI-driven Life Science: Foundation Models and Hallmarks for Cancer
Data- and AI-driven life science represents a paradigm shift for life science, illustrated by several recent breakthroughs, such as alpha-fold, computational drug discovery and the large language models. The Data-Driven Life Science (DDLS) program that SciLifeLab coordinates and KAW funds in Sweden will create critical mass, recruit global expertise, and promote training in data-driven life science to meet the future challenges and opportunities.
In the second part of the talk, our approach to create Data-Driven Hallmarks (DDHMs) for cancer, inspired by the Weinberg-Hanahan cancer hallmark concept (Hanahan, 2022), will be described. Here, we first acquired genomics, transcriptomics, epigenetics, and proteomics data from about 150 AML samples, alongside ex-vivo drug response data for over 500 drugs. From a total of about 100 million data points (Erkers et al., 2023, we discerned 11 dimensions of variability. This concise set of DDHMs could provide diagnostic biomarkers for the hallmarks as well as the associated drug susceptibilities. This could pave the way for personalized drug treatments and combinations. This methodology holds the potential to accelerate the realization of data-driven precision medicine's benefits for cancer patients.
About the speaker
Olli Kallioniemi, M.D., Ph.D. is director of the Science for Life Laboratory (www.SciLifeLab.se), a national infrastructure for life sciences in Sweden and professor in Molecular Precision Medicine at the Karolinska Institutet. He also directs the national SciLifeLab-KAW program on Data-Driven Life Science (DDLS).
Olli Kallioniemi was previously (2007-2015) the founding director of FIMM – the Institute for Molecular Medicine Finland at the University of Helsinki, as part of the Nordic EMBL partnership in Molecular Medicine.
Olli Kallioniemi is elected member of European Molecular Biology Organization (EMBO), European Academy of Cancer Sciences, the Nobel Assembly at the Karolinska Institutet, the Royal Swedish Academy of Sciences, and the Knut & Alice Wallenberg Foundation Scientific Council.
Publications on technology development, translational cancer research and precision medicine. Altogether 415 in Pubmed, 633 in WoS (52,893 citations), H-index 115.
Meet the speaker
If you wish to meet and discuss with Olli Kallioniemi on Tuesday Nov. 28th, you are welcome to book a time slot on jotform.
About the seminar series
Once a month, NCMM invites international guest speakers to present on topics within molecular life science and medicine. The seminar is open to all, with no registration needed. Tea, coffee and a simple lunch will be served before the start of the seminar.