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About the speaker
The Ali lab aims to develop a deeper understanding of heterocellular tumour ecosystems and to translate their discoveries for patient benefit. They develop tools to precisely define cell phenotypes within intact tissues in order to model tumours as heterocellular ecosystems.
Read more about the work of Raza Ali and his lab at their website.
Meet the speaker
If you want to meet Dr. Raza Ali on Tuesday Sept. 26th at Forskningsparken, please book a time slot here using jotform.
Abstract
Highly multiplexed imaging for precision breast immuno-oncology
The diagnosis and treatment of breast cancer continues to rely on decades-old techniques in traditional histopathology. Immunotherapy has proved effective among some patients but not others, and this variation is poorly explained by traditional assays. Using imaging mass cytometry – a technique that couples antibodies conjugated to rare earth metal reporters and time-of-flight mass spectrometry to infer epitope abundance at subcellular resolution – my group has shown that the complexity of the TME can be reliably enumerated in situ and used to predict response in a large randomised trial of neoadjuvant immunotherapy in triple-negative breast cancer. Moreover, we show how immunotherapy remodels the TME, and how resistant cancer cells endure treatment by analysing serial samples collected over the treatment course. I will share our results and offer some insights on the wider implications for spatial cancer biology.
About the seminar series
Once a month, NCMM invites guest speakers to present on topics within molecular life science and medicine. The seminar is open to all, with no registration needed. Tea, coffee and a simple lunch will be served before the start of the seminar.