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About the speaker
Denes is a Max Planck Group leader in the Max Planck Institute for Molecular Genetics in Berlin. After completing his postdoctoral training in the laboratory of Professor Richard Young at the Whitehead Institute of Biomedical Sciences in Cambridge, USA.Throughout his career, Denes has made several important contributions to our understanding of the molecular mechanisms of gene regulation control through super-enhancers, formation of transcriptional condensates, and their role in human diseases.
Abstract
Transcriptional condensates in health and disease
The mission of the Hnisz laboratory is to discover principles that underlie control of transcriptional programs during development and disease. We recently proposed a model that transcriptional regulatory proteins form nuclear condensates that play important roles in the control of cell identity of mammalian cells. The central theme of the lab is to use the transcriptional condensate model to solve major outstanding problems in transcription- developmental- and disease biology. I will describe new insights into the molecular basis of condensate formation, regulatory functions of transcriptional condensates, and their alterations in genetic diseases in humans.
About the seminar series
Once a month, NCMM invites international guest speakers to present on topics within molecular life science and medicine.
The seminar is open to all, with no registration needed.
Tea, coffee and a simple lunch will be served before the start of the seminar.
NCMM International seminar schedule for 2024 can be found here.