Many congratulations to the Sekulic Group on their review article, which has been published in the the journal Essays in Biochemistry.
Abstract
The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, we summarize findings from recent structural biology studies, including several CryoEM structures, that contributed to elucidate specific features of the CENP-A nucleosome and molecular determinants of its interactions with CENP-C and CENP-N, the only two centromere proteins that directly bind to it. Based on those findings, we propose a role of the CENP-A nucleosome in the organization of centromeric chromatin beyond binding centromeric proteins.
You can read the article in full via the Essays in Biochemistry website: 'CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology'. Ahmad Ali Ahmad and Nikolina Sekulic. Essays Biochem (2020) 64 (2): 205–221.
https://doi.org/10.1042/EBC20190074