JASPAR is a comprehensive open-access database of curated, non-redundant transcription factor binding motifs. Each month, about 15 000 users access the database. The Mathelier group at NCMM and collaborators have now released the 10th update of the database, adding more motifs and functional updates.
The 10th JASPAR update was recently published in Nucleic Acids Research.
JASPAR allows for analysis and visualization of transcription factor binding motifs
Transcription factors are like conductors of an orchestra, guiding the activity of genes encoded in our genome. They ensure that each gene, like a musician, plays its part at the right time and volume, creating a harmonious symphony in our cells. To control gene activity, transcription factors bind specific motifs within the genome.
The JASPAR database stores experimentally defined transcription factor binding motifs and offers tools for their analysis and visualization to the community. It helps in understanding how transcription factors interact with the DNA to control gene activities, and in identifying where these interactions occur in the DNA sequences. Researchers utilize it for comparative genomics, understanding gene regulatory networks, and interpreting the impact of genetic variations.
Current update increases motifs, improves quality and adds new tool
The latest 20-year anniversary JASPAR release comes with several exciting updates:
- 329 new motifs have been added, representing a 20% increase.
- Quality improvements were made to existing motifs, making the data more reliable.
- A new technique was used to refine the motifs, enhancing their accuracy.
- A new tool has been introduced, making it easier for users to explore specific gene control regions.
Members of the Mathelier group worked together on the 10th JASPAR update. Photo: Anthony Mathelier.
The 20-year evolution of JASPAR
The first release of JASPAR happened in 2004 and was an effort lead by Albin Sandelin, Wyeth Wasserman, and Boris Lenhard. It started as the first open-access database providing detailed DNA binding motifs for transcription factors. It is now an international collaborative effort that is led by scientific groups from 5 countries for the 2024 release.
Emphasizing high-quality, user-friendly content, JASPAR expanded significantly over the years, incorporating new technologies and growing its database. A strong advocate of open science, it has integrated various resources to promote data sharing and community engagement. This journey reflects JASPAR's commitment to advancing genetic research, by constantly adapting to technological advancements and user needs. This has made it an essential tool in understanding the complexities of gene regulation.
To summarize, JASPAR has evolved remarkably through its 10 releases spanning 20 years of work. Nevertheless, it has consistently upheld its core principles of (i) providing high-quality transcription factor binding motifs, (ii) fostering open access, and (iii) ensuring ease of use.