Martin Rainer Wohlwend

• Wohlwend, Martin; Laurila, Pirkka-Pekka; Williams, Kristine; Romani, Mario; Lima, Tanes & Pattawaran, Pattamaprapanont [Vis alle 15 forfattere av denne artikkelen] (2021). The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging. Science Translational Medicine. ISSN 1946-6234. 13(623). doi: 10.1126/scitranslmed.abc7367. Vis sammendrag

  Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to be elucidated. Here, we identified an exercise-induced long noncoding RNA, CYTOR, whose exercise responsiveness was conserved in human and rodents. Cytor overexpression in mouse myogenic progenitor cells enhanced myogenic differentiation by promoting fast-twitch cell fate, whereas Cytor knockdown deteriorated expression of mature type II myotubes. Skeletal muscle Cytor expression was reduced upon mouse aging, and Cytor expression in young mice was required to maintain proper muscle morphology and function. In aged mice, rescuing endogenous Cytor expression using adeno-associated virus serotype 9 delivery of CRISPRa reversed the age-related decrease in type II fibers and improved muscle mass and function. In humans, CYTOR expression correlated with type II isoform expression and was decreased in aged myoblasts. Increased CYTOR expression, mediated by a causal cis–expression quantitative trait locus located within a CYTOR skeletal muscle enhancer element, was associated with improved 6-min walk performance in aged individuals from the Helsinki Birth Cohort Study. Direct CYTOR overexpression using CRISPRa in aged human donor myoblasts enhanced expression of type II myosin isoforms. Mechanistically, Cytor reduced chromatin accessibility and occupancy at binding motifs of the transcription factor Tead1 by binding, and hence sequestering, Tead1. In conclusion, the long noncoding RNA Cytor was found to be a regulator of fast-twitch myogenesis in aging.

• Moreira, Jose Bianco Nascimento; Wohlwend, Martin & Wisløff, Ulrik (2020). Exercise and cardiac health: physiological and molecular insights. Nature Metabolism. doi: 10.1038/s42255-020-0262-1.
• Williams, Kristine; Ingerslev, Lars; Bork-Jensen, Jette; Wohlwend, Martin; Normann hansen, Ann & Lewin, Small [Vis alle 14 forfattere av denne artikkelen] (2019). Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. Nature Communications. ISSN 2041-1723.
• Stølen, Tomas; Shi, Mingshu; Wohlwend, Martin; Høydal, Morten; Bathen, Tone Frost & Ellingsen, Øyvind [Vis alle 7 forfattere av denne artikkelen] (2019). Effect of exercise training on cardiac metabolism in rats with heart failure. Scandinavian Cardiovascular Journal. ISSN 1401-7431. s. 1–8. doi: 10.1080/14017431.2019.1658893.
• Moreira, Jose Bianco Nascimento; Wohlwend, Martin; Fenk, Simone; Åmellem, Ingrid; Flatberg, Arnar & Kraljević, Jasenka [Vis alle 10 forfattere av denne artikkelen] (2019). Exercise reveals proline dehydrogenase as a potential target in heart failure. Progress in cardiovascular diseases. ISSN 0033-0620. 62(2), s. 193–202. doi: 10.1016/j.pcad.2019.03.002.
• Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo & Moreira, Jose Bianco Nascimento [Vis alle 16 forfattere av denne artikkelen] (2018). Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-35728-2. Fulltekst i vitenarkiv
• Smenes, Benedikte; Bækkerud, Fredrik Hjulstad; Slagsvold, Katrine Hordnes; Hassel, Erlend; Wohlwend, Martin & Pinho, Maria [Vis alle 10 forfattere av denne artikkelen] (2018). Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 27(1), s. 95–101. doi: 10.1093/icvts/ivx439. Fulltekst i vitenarkiv
• van Schaardenburgh, Michel; Wohlwend, Martin Rainer; Rognmo, Øivind & Mattsson, Erney (2017). Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. Journal of Translational Medicine. ISSN 1479-5876. 15(130). doi: 10.1186/s12967-017-1232-6. Fulltekst i vitenarkiv
• Bowen, Scott; Aakerøy, Lars; Eisenkolb, Sophia; Kunth, Patricia; Bækkerud, Fredrik Hjulstad & Wohlwend, Martin Rainer [Vis alle 13 forfattere av denne artikkelen] (2017). Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 49(5), s. 879–887. doi: 10.1249/MSS.0000000000001195.
• Wohlwend, Martin Rainer; Olsen, Alexander; Håberg, Asta & Palmer, Helen (2017). Exercise Intensity-Dependent Effects on Cognitive Control Function during and after Acute Treadmill Running in Young Healthy Adults. Frontiers in Psychology. ISSN 1664-1078. 8. doi: 10.3389/fpsyg.2017.00406. Fulltekst i vitenarkiv Vis sammendrag

  The idea that physical activity differentially impacts upon performance of various cognitive tasks has recently gained increased interest. However, our current knowledge about how cognition is altered by acute physical activity is incomplete. To measure how different intensity levels of physical activity affect cognition during and after 1 bout of physical activity, 30 healthy, young participants were randomized to perform a not-X continuous performance test (CPT) during low (LI)- and moderate intensity (MI) running. The same participants were subsequently randomized to perform the not-X CPT post LI, MI, and high intensity (HI) running. In addition, exercise related mood changes were assessed through a self-report measure pre and post running at LI, MI, and HI. Results showed worsening of performance accuracy on the not-X CPT during one bout of moderate compared to low intensity running. Post running, there was a linear decrease in reaction time with increasing running intensity and no change in accuracy or mood. The decreased reaction times post HI running recovered back to baseline within 20 min. We conclude that accuracy is acutely deteriorated during the most straining physical activity while a transient intensity-dependent enhancement of cognitive control function is present following physical activity.

• van Schaardenburgh, Michel; Wohlwend, Martin Rainer; Rognmo, Øivind & Mattsson, Erney (2017). Calf raise exercise increases walking performance in patients with intermittent claudication. Journal of Vascular Surgery. ISSN 0741-5214. 65(5), s. 1473–1482. doi: 10.1016/j.jvs.2016.12.106. Fulltekst i vitenarkiv
• van Schaardenburgh, Michel; Wohlwend, Martin Rainer; Rognmo, Øivind & Mattsson, Erney (2016). Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE. ISSN 1932-6203. 11:e0165038(10). doi: 10.1371/journal.pone.0165038. Fulltekst i vitenarkiv
• Moreira, Jose Bianco Nascimento; Wohlwend, Martin; Åmellem, Ingrid & Jannig, Paulo R. (2016). Age-dependent effects of bed rest in human skeletal muscle: Exercise to the rescue. Journal of Physiology. ISSN 0022-3751. 594(2), s. 265–266. doi: 10.1113/JP271758.
• Moreira, Jose Bianco Nascimento; Wohlwend, Martin; Alves, Marcia Netto Magalhaes; Wisløff, Ulrik & Bye, Anja (2015). A small molecule activator of AKT does not reduce ischemic injury of the rat heart. Journal of Translational Medicine. ISSN 1479-5876. 13(1). doi: 10.1186/s12967-015-0444-x. Fulltekst i vitenarkiv

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• van Schaardenburgh, Michel; Wohlwend, Martin; Rognmo, Øivind & Mattsson, Erney (2017). Patients with intermittent claudication decrease or increase walking performance after an exercise intervention and this response relates to mitochondrial function.
• van Schaardenburgh, Michel; Wohlwend, Martin; Rognmo, Øivind & Mattsson, Erney (2017). Training Of Claudicants Can Also Be Harmful.
• Wohlwend, Martin Rainer (2017). Exercise regulated long noncoding RNAs.
• Wohlwend, Martin Rainer; Chawla, Konika; Wisløff, Ulrik & Moreira, Jose Bianco Nascimento (2017). Exercise regulates expression of long noncoding RNAs.
• Wohlwend, Martin Rainer; Wisløff, Ulrik; Nes, Bjarne & Nauman, Javaid (2017). Personal Activity Intelligence (PAI) for promotion of physical activity and prevention of CVD .
• Wohlwend, Martin Rainer; Chawla, Konika; Wisløff, Ulrik & Moreira, Jose Bianco Nascimento (2017). Exercise regulates expression of long noncoding RNAs.
• van Schaardenburgh, Michel; Wohlwend, Martin Rainer; Rognmo, Øivind & Mattsson, Erney (2016). "Fem pluss" Legghevingstrening forbedrer gangdistanse hos pasenter med Clauducatio Intermittens.
• Wohlwend, Martin; Andenæs, Kine; Shahab, Ali; Moreira, Jose Bianco Nascimento; Hassel, Erlend & Bye, Anja [Vis alle 7 forfattere av denne artikkelen] (2014). Exercise modality specific adaptations in skeletal muscle of elderly people.
• Wohlwend, Martin; Stølen, Tomas; Høydal, Morten; Wisløff, Ulrik & Rognmo, Øivind (2014). Exercise recovers mitochondrial function in left ventricle of rats inbred for low intrinsic running capacity.
• Esmaeili, Morteza; Stølen, Tomas; Wohlwend, Martin; Høydal, Morten Andre; Rognmo, Øivind & Bathen, Tone Frost [Vis alle 7 forfattere av denne artikkelen] (2014). Post-exercise impacts on energy metabolism of heart failure rats.
• Esmaeili, Morteza; Stølen, Tomas; Wohlwend, Martin; Høydal, Morten Andre; Rognmo, Øivind & Bathen, Tone [Vis alle 7 forfattere av denne artikkelen] (2014). High resolution 31P MR spectroscopy reveals post-exercise impacts on energy metabolism of heart failure rats.
• Wohlwend, Martin; Stølen, Tomas; Høydal, Morten; Wisløff, Ulrik & Rognmo, Øivind (2013). Aerobic interval training recovers differences in mitochondrial function between rats inbred for low- and high aerobic capacity.
• Wohlwend, Martin; Olsen, Alexander; Håberg, Asta & Palmer, Helen (2012). Investigating the reticular-activating hypofrontality model of acute exercise with Conner´s Continuous Performance test in combination with treadmill running and transcranial direct current stimulation.
• Wohlwend, Martin; Olsen, Alexander; Håberg, Asta & Palmer, Helen (2012). The effect of exercise on executive function – Investigating an alternative explanation for “Runner’s High”.
• Wohlwend, Martin (2021). Exercise and the dark human genome reveal gene-targets in age-related diseases. Norwegian University of Science and Technology.

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