Sebastian Martin Waszak

• Haas-Kogan, Daphne A.; Aboian, Mariam S.; Minturn, Jane E.; Leary, Sarah E S; Abdelbaki, Mohamed S. & Goldman, Stewart [Vis alle 20 forfattere av denne artikkelen] (2023). Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial. Journal of Clinical Oncology. ISSN 0732-183X. 42(4), s. 441–451. doi: 10.1200/JCO.23.01838. Fulltekst i vitenarkiv
• Waszak, Sebastian Martin (2022). Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping. bioRxiv. ISSN 2692-8205. doi: 10.1101/2022.03.15.483816.
• Waszak, Sebastian Martin (2022). Copy-number dosage regulates telomere maintenance and disease-associated pathways in neuroblastoma. bioRxiv. ISSN 2692-8205. doi: 10.1101/2022.08.16.504100.
• Messinger, Dana; Harris, Micah K; Cummings, Jessica R; Chase, Thomas; Yang, Tao & Sweha, Stefan R [Vis alle 38 forfattere av denne artikkelen] (2022). Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma. Neuro-Oncology. ISSN 1522-8517. doi: 10.1093/neuonc/noac141. Fulltekst i vitenarkiv
• Kratz, Christian P.; Smirnov, Dmitrii; Autry, Robert; Jäger, Natalie; Waszak, Sebastian Martin & Großhennig, Anika [Vis alle 13 forfattere av denne artikkelen] (2022). Heterozygous BRCA1 and BRCA2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents With Cancer. Journal of the National Cancer Institute. ISSN 0027-8874. 114(11), s. 1523–1532. doi: 10.1093/jnci/djac151. Fulltekst i vitenarkiv
• Llamazares-Prada, Maria; Espinet, Elisa; Mijosek, Vedrana; Schwartz, Uwe; Lutsik, Pavlo & Tamas, Raluca [Vis alle 27 forfattere av denne artikkelen] (2021). Versatile workflow for cell type–resolved transcriptional and epigenetic profiles from cryopreserved human lung. JCI Insight. ISSN 2379-3708. doi: 10.1172/jci.insight.140443. Fulltekst i vitenarkiv
• Waszak, Sebastian Martin (2020). Pan-cancer analysis of whole genomes. Nature. ISSN 0028-0836. doi: 10.1038/s41586-020-1969-6.
• Waszak, Sebastian Martin (2020). Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma. Journal of Clinical Oncology. ISSN 0732-183X. doi: 10.1200/JCO.19.00577.
• Waszak, Sebastian Martin (2020). Germline Elongator mutations in Sonic Hedgehog medulloblastoma. Nature. ISSN 0028-0836. doi: 10.1038/s41586-020-2164-5.
• Bonner, Erin R; Waszak, Sebastian Martin; Grotzer, Michael A; Mueller, Sabine & Nazarian, Javad (2020). Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells. Neuro-Oncology. ISSN 1522-8517. doi: 10.1093/neuonc/noaa283. Vis sammendrag

  ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic for the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult patients with highly aggressive brain tumors has shown remarkable clinical responses to ONC201, and recently, the more potent derivative ONC206 entered clinical trials as a single agent for the treatment of CNS cancers. Despite the emerging clinical interest in the utility of imipridones, their exact molecular mechanisms are not fully described. In fact, the existing literature points to multiple pathways (e.g. TRAIL signaling, dopamine receptor antagonism, and mitochondrial metabolism) as putative drug targets. We have performed a comprehensive literature review and highlighted mitochondrial metabolism as the major target of imipridones. In support of this, we performed a meta-analysis of an ONC201 screen across 539 human cancer cell lines and showed that the mitochondrial protease ClpP is the most significant predictive biomarker of response to treatment. Herein, we summarize the main findings on the anticancer mechanisms of this potent class of drugs, provide clarity on their role, and identify clinically relevant predictive biomarkers of response.

• Waszak, Sebastian Martin (2018). Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. The Lancet Oncology. ISSN 1470-2045. doi: 10.1016/S1470-2045(18)30242-0.

Se alle arbeider i Cristin

• Kriener, Birgit & Waszak, Sebastian Martin (2023). A deep learning approach to infer somatic alterations in glioma using digital tissue slides.
• Banono, Nancy Saana; Gawel, Kinga Aurelia; Mäki-Marttunen, Tuomo; van der Ent, Wietske; Kukula-Koch, Wirginia & Fyhn, Marianne [Vis alle 10 forfattere av denne artikkelen] (2023). Novel zebrafish model for studying neurodevelopment in Timothy syndrome.
• Waszak, Sebastian Martin (2022). Mapping the genetic and cellular origin of DIPG/DMG in clinical trials.
• Waszak, Sebastian Martin (2022). Reconstructing the past, predicting the future: mapping the genetic and cellular origin of brain tumors.
• Mottl, Sophie; Sill, Martin; Northcott, Paul A.; Jäger, Natalie; Pfister, Stefan M & Waszak, Sebastian Martin (2022). Parent-of-origin-specific genetic predisposition to medulloblastoma.
• Kriener, Birgit; Mueller, Sabine & Waszak, Sebastian Martin (2022). Digital pathology in neuro-oncology: deep learning-based prediction of clinically-actionable genomic alterations from histopathological images.
• Kriener, Birgit & Waszak, Sebastian Martin (2022). Digital pathology in neuro-oncology: Towards deep learning-based prediction of clinically-actionable genomic alterations from histopathological images.
• Waszak, Sebastian Martin (2022). Genetic origin and somatic evolution of childhood medulloblastoma.
• Waszak, Sebastian Martin (2022). Genetic origin and somatic evolution of childhood brain tumors.
• Waszak, Sebastian Martin (2022). Reconstructing the past, predicting the future: using somatic genomes to identify the cellular origin of childhood cancers.
• Waszak, Sebastian Martin (2022). Reconstructing the past and predicting the future: novel methods to map the genetic and cellular origin of brain tumors.
• Waszak, Sebastian Martin (2022). Genetic Origin and Somatic Evolution of Childhood Medulloblastoma.

Se alle arbeider i Cristin