Siste publikasjoner for Bioteknologisenteret i Oslo

• Dorfman, Mauricio D; Krull, Jordan E; Scarlett, Jarrad M; Guyenet, Stephan J; Sajan, Mini P. & Damian, Vincent [Vis alle 12 forfattere av denne artikkelen] (2017). Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. ISSN 0012-1797. 66(4), s. 920–934. doi: 10.2337/db16-0482.
• Moltu, Kristine; Henjum, Karen; Oberprieler, Nikolaus; Bjørnbeth, Bjørn Atle & Tasken, Kjetil (2017). Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2. Human Immunology. ISSN 0198-8859. 78(2), s. 129–137. doi: 10.1016/j.humimm.2016.10.007. Fulltekst i vitenarkiv
• Dukic, Aleksandra; McClymont, David & Tasken, Kjetil (2017). A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM. Journal of Biomolecular Screening. ISSN 1087-0571. 22(1), s. 77–85. doi: 10.1177/1087057116669120. Fulltekst i vitenarkiv
• Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Subramani, Saranya; Melum, Espen & Line, Pål Dag [Vis alle 10 forfattere av denne artikkelen] (2017). CD8+ T cells that coexpress ROR?t and T-bet are functionally impaired and expand in patients with distal bile duct cancer. Journal of Immunology. ISSN 0022-1767. 198(4), s. 1729–1739. doi: 10.4049/jimmunol.1600061.
• Martîn, Ruth Martîn; Portantier, Marina; Chica-Balaguera, Nathalia; Nyquist-Andersen, Mari; Mata, J & Lopez-Aviles, Sandra (2017). A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast. Current Biology. ISSN 0960-9822. 27(2), s. 175–188. doi: 10.1016/j.cub.2016.11.037. Fulltekst i vitenarkiv
• Thimiri Govinda Raj, Deepak Balaji & Khan, Niamat Ali (2016). Designer nanoparticle: Nanobiotechnology tool for cell biology. Nano Convergence. 3(1). doi: 10.1186/s40580-016-0082-x.
• Shabrova, Elena; Hoyos, Beatrice; Vinogradov, Valerie; Kim, Youn-Kyung; Wassef, Lesley & Leitges, Michael [Vis alle 8 forfattere av denne artikkelen] (2016). Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity. The FASEB Journal. ISSN 0892-6638. s. 1339–1355. doi: 10.1096/fj.15-281543.
• Haller, Martina; Khalid, Sana; Kremser, Leopold; Fresser, Friedrich; Furlan, Tobias & Hermann, Martin [Vis alle 13 forfattere av denne artikkelen] (2016). Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc. Journal of Biological Chemistry. ISSN 0021-9258. 291(45), s. 23557–23568. doi: 10.1074/jbc.m116.752766.
• Nakanishi, Yuki; Reina-Campos, Miguel; Nakanishi, Naoko; Llado, Victoria; Elmen, Lisa & Peterson, Scott [Vis alle 14 forfattere av denne artikkelen] (2016). Control of Paneth cell fate, intestinal inflammation and tumorigenesis by PKCλ/ι. Cell reports. ISSN 2211-1247. 16. doi: 10.1016/j.celrep.2016.08.054.
• Bjerregaard-Andersen, Kaare; Østensen, Ellen; Scott, John D.; Tasken, Kjetil & Morth, Jens Preben (2016). Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. ISSN 1744-3091. 72, s. 591–597. doi: 10.1107/S2053230X16010189. Vis sammendrag

  A-kinase anchoring proteins (AKAPs) are a family of proteins that provide spatiotemporal resolution of protein kinase A (PKA) phosphorylation. In the myocardium, PKA and AKAP18γ/δ are found in complex with sarcoendoplasmic reticulum Ca2+-ATPase 2 (SERCA2) and phospholamban (PLB). This macromolecular complex provides a means by which anchored PKA can dynamically regulate cytoplasmic Ca2+ release and re-uptake. For this reason, AKAP18γ/δ presents an interesting drug target with therapeutic potential in cardiovascular disease. The crystal structure of the central domain of human AKAP18γ has been determined at the atomic resolution of 1.25 Å. This first structure of human AKAP18γ is trapped in a novel conformation by a malonate molecule bridging the important R-loop with the 2H phosphoesterase motif. Although the physiological substrate of AKAP18γ is currently unknown, a potential proton wire deep in the central binding crevice has been indentified, leading to bulk solvent below the R-loop. Malonate complexed with AKAP18γ at atomic resolution provides an excellent starting point for structure-guided drug design.

• Kim, Yun K; Yadava, Ramesh S; Mandal, Mahua; Mahadevan, Karunasai; Yu, Qing & Leitges, Michael [Vis alle 7 forfattere av denne artikkelen] (2016). Disease phenotypes in a mouse model of RNA toxicity are independent of protein kinase Cα and Protein Kinase Cβ. PLOS ONE. ISSN 1932-6203. 11(9). doi: 10.1371/journal.pone.0163325.
• Sajan, Mini; Hansen, Barbara; Ivey, RA 3rd; Sajan, Joshua; Ari, Csilla & Song, Shijie [Vis alle 10 forfattere av denne artikkelen] (2016). Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1a and increases in Aβ<sub>1-40/42</sub> and phospho-tau may abet Alzheimer development. Diabetes. ISSN 0012-1797. 65(7), s. 1892–1903. doi: 10.2337/db15-1428.
• Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2016). The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. BMC Infectious Diseases. ISSN 1471-2334. 16:599, s. 1–12. doi: 10.1186/s12879-016-1938-8. Fulltekst i vitenarkiv
• Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn & Gavasso, Sonia [Vis alle 7 forfattere av denne artikkelen] (2016). Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. Pharmacological Research. ISSN 1043-6618. 113, s. 216–227. doi: 10.1016/j.phrs.2016.08.018. Fulltekst i vitenarkiv
• Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne & Trøseid, Marius [Vis alle 8 forfattere av denne artikkelen] (2016). Plasma IP-10 is increased in immunological nonresponders and associated with activated regulatory T cells and persisting low CD4 counts. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 73(2), s. 138–148. doi: 10.1097/QAI.0000000000001080.
• Gunasekaran, Stalin Chellappa; Lieske, Nora Valeska; Hagness, Morten; Line, Pål Dag; Tasken, Kjetil & Aandahl, Einar Martin (2016). Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells. Journal of Leukocyte Biology. ISSN 0741-5400. 100(1), s. 5–16. doi: 10.1189/jlb.2HI0815-334R.
• Gerner, Lisa; Munack, Steffi; Temmerman, Koen; Lawrence-Dörner, Ann-Marie; Besir, Huseyin & Wilmanns, Matthias [Vis alle 10 forfattere av denne artikkelen] (2016). Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli. Data in Brief. ISSN 2352-3409. 8, s. 733–740. doi: 10.1016/j.dib.2016.06.033.
• Wehbi, Vanessa Leila & Tasken, Kjetil (2016). Molecular mechanisms for cAMP-mediated immunoregulation in T cells - role of anchored protein kinase a signaling units. Frontiers in Immunology. ISSN 1664-3224. 7:222. doi: 10.3389/fimmu.2016.00222.
• Przybyl, Lukasz; Haase, Nadine; Golic, Michaela; Rugor, Julianna; Solano, Maria Emilia & Arck, Petra Clara [Vis alle 23 forfattere av denne artikkelen] (2016). CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia. Circulation Research. ISSN 0009-7330. 119(1), s. 55–68. doi: 10.1161/CIRCRESAHA.116.308304.
• Falk, Samantha J.; Lee, Jaehyoun; Sekulic, Nikolina; Sennett, Michael A.; Lee, Tae-Hee & Black, Ben E. (2016). CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres. Nature Structural & Molecular Biology. ISSN 1545-9993. 23(3), s. 204–208. doi: 10.1038/nsmb.3175.
• Gunasekaran, Stalin Chellappa; Hugenschmidt, Harald; Hagness, Morten; Line, Pål Dag; Labori, Knut Jørgen & Wiedswang, Gro [Vis alle 8 forfattere av denne artikkelen] (2016). Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer. Oncoimmunology. ISSN 2162-4011. 5(4). doi: 10.1080/2162402X.2015.1102828.
• Liu, Lisa L.; Landskron, Johannes; Ask, Eivind Heggernes; Enqvist, Monika; Sohlberg, Ebba & Traherne, James A. [Vis alle 18 forfattere av denne artikkelen] (2016). Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans. Cell reports. ISSN 2211-1247. 15(3), s. 1088–1099. doi: 10.1016/j.celrep.2016.04.005.
• Liou, Geou-Yarh; Döppler, Heike; DelGiorno, Kathleen E; Zhang, Lizhi; Leitges, Michael & Crawford, Howard C. [Vis alle 8 forfattere av denne artikkelen] (2016). Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell reports. ISSN 2211-1247. 14(10), s. 2325–2336. doi: 10.1016/j.celrep.2016.02.029.
• Bousquet, Paula; Sandvik, Joe Alexander; Arntzen, Magnus Øverlie; Edin, Nina Frederike J; Christoffersen, Stine & Krengel, Ute [Vis alle 8 forfattere av denne artikkelen] (2015). Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics. ISSN 2090-2174. doi: 10.1155/2015/678527.
• Arntzen, Magnus Øverlie; Boddie, Paul; Frick, Rahel; Koehler, Christian & Thiede, Bernd (2015). Consolidation of proteomics data in the Cancer proteomics database. Proteomics. ISSN 1615-9853. 15(22), s. 3765–3771. doi: 10.1002/pmic.201500144.
• Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima & Nilsen, Hilde [Vis alle 9 forfattere av denne artikkelen] (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell. ISSN 0092-8674. 157(4). doi: 10.1016/j.cell.2014.03.026. Vis sammendrag

  Mitochondrial dysfunction is a common feature in neurodegeneration and aging.We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA-deficient cells show defective mitophagy with excessive cleavage of PINK1 and increased mitochondrial membrane potential. The mitochondrial abnormalities appear to be caused by decreased activation of the NAD+-SIRT1-PGC-1a axis triggered by hyperactivation of the DNA damage sensor PARP- 1. This phenotype is rescued by PARP-1 inhibition or by supplementation with NAD+ precursors that also rescue the lifespan defect in xpa-1 nematodes. Importantly, this pathogenesis appears common to ataxia-telangiectasia and Cockayne syndrome, two other DNA repair disorders with neurodegeneration, but absent in XPC, a DNA repair disorder without neurodegeneration. Our findings reveal a nuclearmitochondrial crosstalk that is critical for the maintenance of mitochondrial health.

• Jourdain, Isabelle; Brzezińska, Elspeth A. & Toda, Takashi (2013). Fission Yeast Nod1 Is a Component of Cortical Nodes Involved in Cell Size Control and Division Site Placement. PLOS ONE. ISSN 1932-6203. 8(1). doi: 10.1371/journal.pone.0054142.

Se alle arbeider i Cristin

• Nissen-Meyer, Lise Sofie Haug & Chaudhry, Farrukh Abbas (2017). Corrigendum: Protein kinase C phosphorylates the system N glutamine transporter SN1 (Slc38a3) and regulates its Membrane trafficking and Degradation [Front Endocrinol, 4, (2013) (138)] doi: 10.3389/fendo.2013.00138. Frontiers in Endocrinology. ISSN 1664-2392. 8:190, s. 1–2. doi: 10.3389/fendo.2017.00190.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm & Bogen, Bjarne [Vis alle 7 forfattere av denne artikkelen] (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi. February.
• Ribes, Anna Maria Parente; Skånland, Sigrid Strand; Bürgler, Simone; Os, Audun; Wang, Dong & Bogen, Bjarne [Vis alle 9 forfattere av denne artikkelen] (2016). Spleen tyrosine kinase inhibitors reduce CD40l-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells. Haematologica. ISSN 0390-6078. 101(2), s. e59–e62. doi: 10.3324/haematol.2015.135590.
• Johnsen, Guro Mørk; Sheng, Vincent O.Y.; Tasken, Kjetil; Staff, Anne Cathrine & Malmberg, Karl-Johan (2015). Killer immunoglobulin-like receptors (KIRS) on 3rd trimester decidual natural killer cells. Journal of Reproductive Immunology. ISSN 0165-0378. 111. doi: 10.1016/j.jri.2015.06.073.

Se alle arbeider i Cristin