Disruptions in the brain white matter have been hypothesized to give rise to psychotic symptoms, but few studies have looked at this feature in adolescents. A recent study by Claudia Barth and colleagues from the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA)-EOP Working Group, has sought to close this knowledge gap.
This is the largest analysis of brain white matter in adolescents with early onset psychosis (EOP) to date. The results indicate that psychosis may be a disorder of white matter connectivity, not just in adults but also in adolescents. This is important as adolescence is a sensitive time for brain development.
The study has recently been published in Molecular Psychiatry, accompanied by a “behind the paper” blog post explaining the study and the findings in a popular scientific manner.
Reference
- Barth et al., (2022) In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis, Moleculary Psychiatry.
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